CClinicalTrials.gg
Status unknownNCT03194243PURPLEUpdated Oct 10, 2017

Pathway and Urgent caRe of Dyspneic Patient at the Emergency Department in LorrainE District (PURPLE)

An observational study in Acute Dyspnea, sponsored by Central Hospital, Nancy, France. Status unknown at 9 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-10-10.

Sponsored by Central Hospital, Nancy, France · Observational

The sponsor has not verified this record recently (last verified Oct 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
75,000
Ages
18 Years and older
Sex
All
01

Study summary

This is an observational prospective multicenter study of patients admitted for acute dyspnea in an emergency department of the participating centers in the Lorraine district.

The primary objective is to assess the outcome of this population according to the cause of acute dyspnea as well as identify the predictors of this outcome, both overall and according to each acute dyspnea cause.

Read the detailed description

This observational prospective multicenter study will be conducted using data from electronic medical records, acquired as part of usual care, in patients admitted for acute dyspnea in the emergency department. Clinical, treatment, laboratory and imaging data acquired during the hospitalization (in the emergency department and in the department that admitted the patients following the emergency department stay) will be collected.

Vital status will be recorded at 30 days and 1 year post-admission.

02

Conditions studied

  • Acute Dyspnea

Keywords

  • acute dyspnea
  • acute heart failure
  • emergency
03

In context

Dyspnea

656 studies on the registry are indexed under Dyspnea; 153 are open to participants now.

This study's planned enrollment of 75,000 is above the median of 122 across 204 observational studies indexed under Dyspnea.

Browse Dyspnea studies →

Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 778 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with acute dyspnea and treated in an emergency department of the participating centers in the Lorraine district.

Inclusion criteria

  • Men or women > or = 18 years.
  • Patients with acute dyspnea admitted for acute dyspnea in the emergency department.
  • Patient informed.

Exclusion criteria

Exclusion Criteria:

  • Cardiorespiratory arrest.
  • Patient having expressed his or her opposition.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
75,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients admitted for acute dyspnea

    Patients admitted for acute dyspnea in the emergency department

06

What researchers measure

Primary outcomes

  1. All cause mortality

    Time frame: From emergency admission for acute dyspnea up until 1 year

Secondary outcomes

  1. Demographic data

    Time frame: through hospital stay, an average of 10 days

  2. Clinical data

    Time frame: through hospital stay, an average of 10 days

  3. Treatment data

    Time frame: through hospital stay, an average of 10 days

  4. Laboratory data

    Time frame: through hospital stay, an average of 10 days

  5. Imaging data

    Time frame: through hospital stay, an average of 10 days

  6. Duration of hospitalization

    including emergency stay and conventional hospitalization

    Time frame: At final discharge, an average of 10 days after admission

  7. Initial diagnosis in the emergency department

    Time frame: At admission

  8. Final diagnosis of the initial hospitalization stay

    Time frame: At final discharge, an average of 10 days after admission

  9. Brain Natriuretic Peptide

    Time frame: Through hospital stay, an average of 10 days

  10. Estimated glomerular function rate

    Time frame: Through hospital stay, an average of 10 days

  11. Estimated plasma volume

    Time frame: Through hospital stay, an average of 10 days

  12. Liver biological biomarkers

    Time frame: Through hospital stay, an average of 10 days

  13. Urea

    Time frame: Through hospital stay, an average of 10 days

  14. Use of non-invasive ventilation

    Time frame: Through hospital stay, an average of 10 days

  15. Time of use of non-invasive ventilation

    Time frame: Through hospital stay, an average of 10 days

  16. Use of diuretics

    Time frame: Through hospital stay, an average of 10 days

  17. Time of use of diuretics

    Time frame: Through hospital stay, an average of 10 days

  18. Use of nitrates

    Time frame: Through hospital stay, an average of 10 days

  19. Time of use of nitrates

    Time frame: Through hospital stay, an average of 10 days

  20. Department type admitting the patient following emergency management

    intensive care unit, cardiology, cardiac intensive care unit, other ...

    Time frame: Through hospital stay, an average of 10 days

  21. All cause in-hospital mortality

    Time frame: At final discharge, an average of 10 days after admission

07

Study locations

9 of 9 sites recruiting
  • CH Marie-Madeleine FORBACH - Service des Urgences
    Forbach, Lorraine 57604, France
    • Caroline HLADNIK, MD · Contact
    • Caroline HLADNIK, MD · Principal investigator
    Recruiting
  • CH LUNEVILLE - Service des Urgences
    Lunéville, Lorraine 54 301, France
    • Julie THISSE, MD · Contact
    • Julie THISSE, MD · Principal investigator
    Recruiting
  • CHR METZ-THIONVILLE- Hôpital de Mercy- Service des Urgences
    Metz, Lorraine 57085, France
    • Elies ANDRE, MD · Contact
    • Elies ANDRE, MD · Principal investigator
    Recruiting
  • CHRU Nancy - Service des Urgences
    Nancy, Lorraine 54000, France
    • Tahar CHOUIHED, MD · Contact · t.chouihed@chru-nancy.fr · +33 3 83 85 14 96
    • Adrien BASSAND, MD · Contact · a.bassand@chru-nancy.fr · + 33 3 83 85 14 96
    • Tahar CHOUIHED, MD · Principal investigator
    • Adrien BASSAND, MD · Sub investigator
    Recruiting
  • CH PONT A MOUSSON- Service des Urgences
    Pont-à-Mousson, Lorraine 54 701, France
    • Alexandre GROSJEAN, MD · Contact
    • Alexandre GROSJEAN, MD · Principal investigator
    Recruiting
  • CH REMIREMONT - Service des Urgences
    Remiremont, Lorraine 88204, France
    • Marie BREFFA, MD · Contact
    • Marie BREFFA, MD · Principal investigator
    Recruiting
  • CH SAINT-DIE-DES-VOSGES - Service des Urgences
    Saint-Dié-des-Vosges, Lorraine 88100, France
    • Patrice THIRION, MD · Contact
    • Patrice THIRION, MD · Principal investigator
    Recruiting
  • CHR METZ-THIONVILLE- Hôpital Bel-Air- Service des Urgences
    Thionville, Lorraine 57100, France
    • Phillippe SATTONNET, MD · Contact
    • Phillippe SATTONNET, MD · Principal investigator
    Recruiting
  • CH EPINAL - Service des Urgences
    Épinal, Lorraine 88021, France
    • Céline HOMEL, MD · Contact
    • Céline HOMEL, MD · Principal investigator
    • Jean-Dominique RISSER, MD · Sub investigator
    Recruiting
08

References and documents

Publications

  • Buessler A, Chouihed T, Duarte K, Bassand A, Huot-Marchand M, Gottwalles Y, Penine A, Andre E, Nace L, Jaeger D, Kobayashi M, Coiro S, Rossignol P, Girerd N. Accuracy of Several Lung Ultrasound Methods for the Diagnosis of Acute Heart Failure in the ED: A Multicenter Prospective Study. Chest. 2020 Jan;157(1):99-110. doi: 10.1016/j.chest.2019.07.017. Epub 2019 Aug 2. PubMed 31381880 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 10, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03194243
Lead sponsor
Central Hospital, Nancy, France
Responsible party
Sponsor
First posted
Jun 21, 2017
Start date
Oct 5, 2017
Primary completion
Oct 2023 (estimated)
Completion
Oct 2023 (estimated)
Last update
Oct 10, 2017

Study contacts

Tahar CHOUIHED, MD
Contact
t.chouihed@chru-nancy.fr
+ 33 3 83 85 14 96
Nicolas GIRERD, MD,PhD
Contact
n.girerd@chru-nancy.fr
+ 33 3 83 15 74 96
Tahar CHOUIHED, MD
principal investigator · Central Hospital, Nancy, France
Nicolas GIRERD, MD,PhD
principal investigator · Central Hospital, Nancy, France

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.

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