An interventional study of Mechanical Thrombectomy in Acute Stroke, sponsored by Assiut University. Status unknown. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-05-09.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
Assessment of Therapeutic benefits and hazards of Mechanical Thrombectomy in Ischemic stroke patients with proximal occlusion within 4.5 hours from stroke onset.
Stroke is an acute neurologic dysfunction of vascular origin with sudden or at least rapid occurrence of symptoms and signs corresponding to the involvement of focal areas in the brain.The two main types of stroke are ischemic and hemorrhagic.Thrombosis can form in the extracranial and intracranial arteries when the intima is roughened and plaque forms along the injured vessel.The endothelial injury permits platelets to adhere and aggregate, then coagulation is activated and thrombus develops at site of plaque.Blood flow through the extracranial and intracranial systems decreases, and the collateral circulation maintains function. When the compensatory mechanism of collateral circulation fails, perfusion is compromised, leading to decreased perfusion and cell death. Stroke is the third leading cause of death in the United States. Many people die each year from stroke in the United States.Stroke is the leading cause of serious, long-term disability in the United States. Nearly one fourth of strokes occur in people under the age of 65.High blood pressure is the most important risk factor for stroke. Intravenous recombinant tissue-type plasminogen activator is the only Food and Drug Administration approved treatment for acute ischemic stroke. Mechanical thrombectomy improves clinical outcomes in patients with acute ischemic stroke caused by a large vessel occlusion.There is no apparent benefit of intravenous thrombolysis to patients with ischemic stroke undergoing mechanical thrombectomy. The study will be performed involving ischemic stroke patients with proximal occlusion within 4.5 hours from stroke onset.
7,286 studies on the registry are indexed under Stroke; 2,013 are open to participants now.
This study's planned enrollment of 20 is below the median of 50 across 5,366 interventional studies indexed under Stroke.
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Exclusion Criteria:
The study will be performed involving ischemic stroke patients with proximal occlusion within 4.5 hours from stroke onset, mechanical thrombectomy with retrievable stents, thrombus aspiration, retraction, wire disruption.
Procedure: Mechanical Thrombectomy
mechanical thrombectomy with retrievable stents, thrombus aspiration, retraction, wire disruption
Treatment Of Acute Occlusion In Ischemic Stroke by Mechanical Thrombectomy
Treatment of ischemic stroke patients after 4.5 hours from stroke onset by endovascular intervention by using Mechanical Thrombectomy techniques and without using Recombinant tissue-type plasminogen Activator and non eligible patients for Thrombectomy will be excluded. The number of people will be participated into this study will be 20 aged 18 to 80 years old The patients will be undergoing NIHSS score , ASPECTS score The patients will be undergoing CT/CT angiography The patients will be undergoing mechanical thrombectomy Results will be collected and correlated with the prognosis of the outcomes
Time frame: 18 months
The patients will be undergoing NIHSS score
patients with NIHSS score less than 10 non eligible for mechanical thrombectomy
Time frame: 1 hour
The patients will be undergoing ASPECTS score
patients with ASPECTS score less than 6 non eligible for mechanical thrombectomy
Time frame: 1 hour
The patients will be undergoing CT/CT angiography
ct and ct angiography for exclusion of any bleeding or head injury
Time frame: 2 hours
No study locations are listed for this record.
Plan to share: Undecided
This study is status unknown, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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Assiut University