An observational study in Hemophagocytic Lymphohistiocytoses, sponsored by Samsung Medical Center. Recruiting at 1 site in South Korea. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-04-24.
Sponsored by Samsung Medical Center · Observational
This prospective study enrolls subjects who have clinical and laboratory manifestations related with hemophagocytic lymphohistiocytosis. The purpose of the study is to evaluate clinical and biological features of adult hemophagocytic lymphohistiocytosis. The enrolled subjects into this study will be evaluated according to the HLH (hemophagocytic lymphohistiocytosis)criteria and treated with systemic immunosuppressive therapy or chemotherapy. All subjects will be regularly monitored by physicians participating in this study.
Study process is as follows.
Laboratory evaluation will be done for subjects according to the following diagnostic criteria.
Diagnosis will be established if one of either 1 or 2 below is fulfilled
Subjects who have clinical and laboratory manifestations related with hemophagocytic lymphohistiocytosis.
Subjects should fulfill the following criteria
Subjects should have at least one of the following problems
Exclusion Criteria:
Subjects should fulfill the following criteria 1. Subjects should have at least one of the following problems 1. Presence of hemophagocytosis in tissue or bone marrow 2. Presence of at least 3 conditions among 8 conditions of HLH diagnostic criteria 2. Age \> 18 years 3. Written informed consents Subjects receive steroids and etoposide
Drug: Steroids · Drug: Etoposide
High dose dexamethasone 20 mg PO or IV
Also known as: Dexamethasone
Etoposide 150mg/BSA
Response
Response to steroids and etoposide
Time frame: 28 days after the 1st treatment
Progression-free survival
Time to date of progression or any kinds of death
Time frame: 3 years
Overall survival
Time to date of any kinds of death
Time frame: 3 years
Plan to share: Undecided
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Lymphohistiocytosis, Hemophagocytic→
Samsung Medical Center