An interventional study of Sevoflurane and Propofol in General Anesthesia, sponsored by Hôpital Armand Trousseau. Completed at 1 site in France. Open to participants aged 13 Years to 40 Years. Per ClinicalTrials.gov, last updated 2017-04-04.
Sponsored by Hôpital Armand Trousseau · Not applicable, Interventional, and Basic science
Patients were randomized into 2 groups according to the anesthetic, propofol or sevoflurane. Induction and maintenance were standardized, and after the end of surgery, two steady-state recordings were performed at BIS 25 and BIS 55. Bispectral Index and ECG were continuously recorded and cardiac autonomic nervous activity was investigated using spectral analysis of RR Interval variability
Hôpital Armand Trousseau is the lead sponsor of 13 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
General anesthesia using sevoflurane as a hypnotic agent, and remifentanil as an analgesic. Two steady state periods of 10 minutes each, one with a steady bispectral index at 25 +/- 5, the other with a steady bispectral index at 55 +/- 5. Continuous recording of heart rate during the last minute of each steady-state. Off-line spectral analysis of heart rate variability.
Drug: Sevoflurane · Drug: Remifentanil
General anesthesia using propofol as a hypnotic agent, and remifentanil as an analgesic. Two steady state periods of 10 minutes each, one with a steady bispectral index at 25 +/- 5, the other with a steady bispectral index at 55 +/- 5. Continuous recording of heart rate during the last minute of each steady-state. Off-line spectral analysis of heart rate variability.
Drug: Propofol · Drug: Remifentanil
General anesthesia using sevoflurane as a hypnotic agent
General anesthesia using propofol as a hypnotic agent
General anesthesia using remifentanil as an analgesic.
Spectral analysis of heart rate variability with a bispectral index of 25
Fast Fourier Transform applied to heart rate signal recording
Time frame: During surgical procedure
Spectral analysis of heart rate variability with a bispectral index of 55
Fast Fourier Transform applied to heart rate signal recording
Time frame: During surgical procedure
Plan to share: No
No publications or documents are linked to this record.
The record gives a start of Jan 2009, a primary completion of Dec 2009 and a completion of Sep 2010. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drugs tested here: Sevoflurane · Propofol
Hôpital Armand Trousseau