An interventional study of VSL#3 and Placebo in Juvenile Idiopathic Arthritis, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 1 Year to 7 Years. Per ClinicalTrials.gov, last updated 2026-04-06.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Treatment
This study investigates the efficacy of probiotic VSL#3 as an add on standard care on the activity of the disease in patients with Juvenile Idiopathic Arthritis.
Juvenile Idiopathic Arthritis (JIA) is the most frequent rheumatic disorder in children. Numerous studies suggest that alteration of the intestinal barrier may induce abnormal immune responses implicated in development or persistence of arthritis. This paves the way to new therapeutic options aiming to reestablish intestinal homeostasis to treat arthritis or to prevent disease flares. This study investigates the efficacy of probiotic VSL#3 as an add on standard care on the activity of the disease in patients with Juvenile Idiopathic Arthritis.
352 studies on the registry are indexed under Arthritis, Juvenile; 92 are open to participants now.
This study's enrollment of 51 is close to the median of 50 across 225 interventional studies indexed under Arthritis, Juvenile.
Browse Arthritis, Juvenile studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,506 studies on the registry; 1,007 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: VSL#3
Other: Placebo
Dietary Supplement
Placebo
To evaluate the impact of a regular intake of probiotic VSL#3 in addition to standard treatment in patients with JIA on the clinical activity
American College of Rheumatology Pédiatrique score (ACR Pedi )
Time frame: 3 months
To evaluate the impact of a regular intake of probiotic VSL#3 in addition to standard treatment in patients with JIA on the intestinal microbiota.
Stool samples for intestinal microbiota analyses
Time frame: 3 months
Plan to share: No
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This study is completed, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris