An interventional study of Overconsumption of specific dietary nutrient in NAFLD and Nutrient; Excess, sponsored by University of Oxford. Status unknown at 1 site in United Kingdom. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-06-07.
Sponsored by University of Oxford · Not applicable, Interventional, and Basic science
In health,adipose tissue stores fat from the diet. If the fat tissue stops storing dietary fat then this increases the chance of it being stored in the liver, which is related to increased risk of heart disease and type 2 diabetes. It has been suggested that having a diet high in sugars or certain fats, may cause the fat tissue and liver to change how they function; we would like to investigate this in detail.
This research aims to investigate how the overconsumption of specific macronutrients may effect adipose tissue and liver metabolism and function. Liver and heart fat content and adipose tissue and liver metabolism fasting and postprandial lipid metabolism will be assessed before and after the specific dietary intervention.
1,507 studies on the registry are indexed under Non-alcoholic Fatty Liver Disease; 303 are open to participants now.
This study's planned enrollment of 100 is above the median of 60 across 1,098 interventional studies indexed under Non-alcoholic Fatty Liver Disease.
Browse Non-alcoholic Fatty Liver Disease studies →University of Oxford is the lead sponsor of 812 studies on the registry; 119 are open to participants now.
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Exclusion Criteria:
Participants will be asked to consume a relatively low-fat, high-carbohydrate eucaloric diet enriched in free-sugars (20% total energy).
Other: Overconsumption of specific dietary nutrient
Subjects will be studied before and then after the consumption of a diet where specific nutrients are provided in excess.
Liver de novo lipogenesis
Investigators will utilise stable isotope tracer methodology to measure the change in the contribution of newly synthesised fatty acids to very low density lipoprotein triglyceride
Time frame: Within 21 days after starting the intervention diet
Adipose tissue metabolism
Investigators will measure the change in the expression of key lipogenic genes in subcutaneous adipose tissue
Time frame: Within 21 days after starting the intervention diet
Liver fat accumulation
Investigators will measure the change in the amount of fat within the liver using MRI/S
Time frame: Within 21 days after starting the intervention diet
Plan to share: Yes — Following completion of the study, all individual data obtained from participants may potentially be shared with other researchers, both here in the United Kingdom and abroad, in appropriate circumstances. If data is to be shared with other researchers, it will be done so under fully anonymised conditions.
No publications or documents are linked to this record.
Started Mar 2017 (actual). Primary completion is estimated for Mar 2023, 72 months after the start.
Of 323 non-industry interventional studies with no phase under Non-alcoholic Fatty Liver Disease, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 51. This study's planned 72 months is above that.
Counting every sponsor, half of 350 studies reached it within 24 months; a quarter within 12 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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Non-alcoholic Fatty Liver Disease →