An interventional study of Deprexis in MDD, sponsored by Jasper A. Smits. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by Jasper A. Smits · Not applicable, Interventional, and Treatment
The proposed study addresses the potential utility of providing an accessible self-help intervention for patients in a medical setting with an estimated diagnosis of MDD. Specifically, the study will explore whether a) such an intervention can be effectively implemented in a primary care setting and b) patients originally seeking medical attention for an orthopedic problem will be willing to seek psychological treatment and, c) improvement in depression symptoms will lead to improvement in upper and lower extremity functioning.
The present project will be an open-label trial to assess the feasibility and acceptability of a self-help intervention among a sample of orthopedic patients. In addition to monitoring the effectiveness of the Deprexis program on depressive symptoms, the proposed project will assess whether a reduction in depressive symptoms will be associated with improvement on patient reported orthopedic impairment. The investigators will enroll 50 adults and the participants will be given the opportunity to participate in 8 weeks of the web-based online Deprexis program.
Jasper A. Smits is the lead sponsor of 11 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will complete 8 weeks of online treatment via a web-based program, Deprexis.
Behavioral: Deprexis
Participants will complete an 8 week self-help computerized treatments through a web-based online Deprexis program.
Proof of Concept - Acceptability measured by number of eligible participants that choose to participate
The primary outcome will be the level of acceptability of the intervention as measured by the number of eligible participants who chose to participate in the intervention.
Time frame: 8 weeks
Proof of Concept - Acceptability measured by number of modules completed on the online program
The primary outcome will be the level of acceptability of the intervention as measured by number of completed modules on the online Deprexis program.
Time frame: 8 Weeks
Proof of Concept - Acceptability measured by qualitative feedback
The primary outcome will be the level of acceptability of the intervention as measured by qualitative feedback following the intervention created by the investigators on how acceptable the study was for the participant.
Time frame: 8 Weeks
Proof of Concept - Feasibility measured by number of eligible participants that choose to participate
The primary outcome will be the level of feasibility of the intervention as measured by he number of eligible participants who chose to participate in the intervention.
Time frame: 8 Weeks
Proof of Concept - Feasibility measured by number of modules completed on the online program
The primary outcome will be the level of acceptability of the intervention as measured by number of completed modules on the online Deprexis program.
Time frame: 8 Weeks
Proof of Concept - Feasibility measured by qualitative feedback
The primary outcome will be the level of acceptability of the intervention as measured by qualitative feedback following the intervention created by the investigators on how acceptable the study was for the participant.
Time frame: 8 Weeks
Level of Improvement of Depression (by scores on the PHQ-9)
Secondary outcome measures will be the level of depressive symptoms as evidenced by scores on the PHQ-9.
Time frame: 8 weeks
Level of Improvement of Functioning (by scores on the PROMIS Physical Function CAT)
Secondary outcome measure will be the level of improvement in upper and lower extremity function as measured by scores on the PROMIS Physical Function CAT.
Time frame: 8 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Jasper A. Smits