An interventional study of MCG and SCG in Knee Osteoarthritis, sponsored by Boston University Charles River Campus. Terminated at 1 site in United States. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-07-20.
Sponsored by Boston University Charles River Campus · Not applicable, Interventional, and Treatment
This study evaluates the feasibility of a mindful walking intervention for management of knee osteoarthritis. Participants will be randomly assigned to receive one of two interventions i.e. mindful walking intervention or a self-care intervention.
People with knee osteoarthritis have low levels of physical activity, especially walking activity. They also walk with abnormal walking biomechanics that are associated with greater knee loading. Therefore, it is important to increase the levels of walking activity in people with knee osteoarthritis, but also change their walking patterns to reduce knee loading.
This study will last 12 months and participants will be randomized into 2 groups. For the first 6-months, half of the participants will attend sessions at a community location that include training in mindful walking technique. The other half will meet for the same frequency and duration at a community location for education on osteoarthritis and its management (focusing on symptom management, importance of physical activity, weight management, etc.). Both groups will also receive a wrist-worn activity monitor and a smartphone application that they will use throughout the study. After 6-months all participants will be allowed to practice on their own.
All participants will complete gait analysis, knee MRI, questionnaires, physical function assessment at baseline and at 6-months. All participants will also complete questionnaires at 3,9, and 12 months. Weekly physical activity and knee pain data will be collected using the mobile health technology for 12- months.
3,302 studies on the registry are indexed under Osteoarthritis, Knee; 608 are open to participants now.
This study's enrollment of 47 is below the median of 70 across 2,731 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Boston University Charles River Campus is the lead sponsor of 154 studies on the registry; 30 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 8 (57%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will be trained in mindful walking technique
Behavioral: MCG
Participants will receive education in self-management of knee OA
Behavioral: SCG
Community-based in person group training n mindful walking over 11 sessions in 6-months+ Activity monitor with feedback on activity levels
Community-based in person group education in management of knee osteoarthritis (importance of physical activity, weight management, etc.) over 11 sessions in 6 months + Activity monitor with feedback on activity levels
Adherence (in %)
Measured as % of in-person training sessions attended by participants
Time frame: 6-months
Retention (in %)
Measured as the % of participants returning for the post-intervention assessment
Time frame: 6-months
Medial knee contact force during walking (in Newton)
Medial knee contact force derived using an EMG-Driven musculoskeletal model
Time frame: Change from baseline to 6-months
Average Daily Activity Count
Measured using an activity monitor worn by the participants
Time frame: Change from baseline to 6-months
Knee injury and Osteoarthritis Outcome Score (KOOS) Pain Subscale
Patient-reported outcome
Time frame: Change from baseline to 6-months
Arthritis Self Efficacy Scale (ASES)
Patient reported outcome
Time frame: Change from baseline to 6-months
Five Facet Mindfulness Questionnaire (FFMQ)
Patient reported outcome
Time frame: Change from baseline to 6-months
Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire
Patient reported outcome
Time frame: Change from baseline to 6-months
30 second chair stand test (in counts)
Number of time a participant can stand from a chair
Time frame: Change from baseline to 6-months
40 meter fast paced walk test (in seconds)
Time taken to cover 40 meters while walking at a fast pace
Time frame: Change from baseline to 6-months
Stair Climbing Test (in seconds)
Time taken to ascend and descend a set of stairs
Time frame: Change from baseline to 6-months
Knee cartilage composition
MRI t1rho and t2 relaxation times
Time frame: Change from baseline to 6-months
Pain sensitization
Pressure pain threshold, Temporal summation, and conditioned pain modulation
Time frame: Change from baseline to 6-months
Plan to share: Undecided
This study is terminated, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Boston University Charles River Campus