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Status unknownNCT03055975Updated Feb 17, 2017

Prevalence of Bacteria Following Endodontic Treatment

An observational study in Root Canal Infection, sponsored by King's College London. Status unknown at 1 site in United Kingdom. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-02-17.

Sponsored by King's College London · Observational

The sponsor has not verified this record recently (last verified Feb 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
200
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Sampling of accessed root canals with endodontic paper points during treatment and immediately pre-obturation of endodontic root canals was carried out.

Read the detailed description

Following ethical approval (REC ref: 05/Q0705/051), informed consent was obtained from patients undergoing root canal treatment.The teeth included in the study had been referred to a specialist centre for the treatment of endodontic infection. They all responded negatively to vitality tests and presented pre-operative apical radiolucencies. The source population were referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital, King's College London Dental Institute.Treatments on the teeth were carried out by a total of 19 postgraduate endodontic students.

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Conditions studied

  • Root Canal Infection

Keywords

  • Bacteria
  • Root canal treatment
  • Endodontics
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In context

Lead sponsor

King's College London is the lead sponsor of 519 studies on the registry; 126 are open to participants now.

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Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

The source population are adults aged 18-65, referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital, King's College London Dental Institute. Both single- and multi-rooted non-vital teeth are included in the study

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with single or multi-rooted teeth undergoing root canal treatment.

Exclusion criteria

Exclusion Criteria:

  • For certain aspects of the study secondary treatments and vital teeth are excluded.
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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Primary treatments

    Patients undergoing primary root canal treatments. Only teeth which have not previously been accessed are included in this cohort.The source population are adults aged 18-65, referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital

    Diagnostic Test: Detection of residual vital bacteria in the root canal space

  • Re-treatments

    Patients undergoing re-treatments. Only teeth which had a previous root canal treatment which failed are included in this cohort.The source population are adults aged 18-65, referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital

    Diagnostic Test: Detection of residual vital bacteria in the root canal space

Interventions

  • Diagnostic testDetection of residual vital bacteria in the root canal space

    Detection of residual vital bacteria in the root canal space. No intervention, as it is an observational study. Vital bacteria are looked for in the samples taken from the root canal space.

    Also known as: Detection of root canal infection

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What researchers measure

Primary outcomes

  1. Detection of residual bacteria during and post root canal treatment

    Using a vital fluorescent stain bacteria sampled from the root canal space were detected during and post root canal treatment.

    Time frame: June 2016

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Study locations

1 of 1 sites recruiting
  • King's College London, Dental Institute, Floor 22, Endodontics
    London, London SE1 9RT, United Kingdom
    Recruiting
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References and documents

Publications

  • Herzog DB, Hosny NA, Niazi SA, Koller G, Cook RJ, Foschi F, Watson TF, Mannocci F, Festy F. Rapid Bacterial Detection during Endodontic Treatment. J Dent Res. 2017 Jun;96(6):626-632. doi: 10.1177/0022034517691723. Epub 2017 Feb 1. PubMed 28530469 ↗

Individual participant data

Plan to share: Undecided — IPD is not planned to be made available to other researchers as of yet

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Jan 2013 (actual). Primary completion is estimated for May 2017, 52 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 14, 2017
First posted
Feb 16, 2017
StartActual
Jan 30, 2013
Primary completionEst.
May 30, 2017
CompletionEst.
Oct 30, 2018
Last update
Feb 17, 2017
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 17, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03055975
Lead sponsor
King's College London
Collaborators
Guy's and St Thomas' NHS Foundation Trust
Responsible party
Dr Federico Foschi (Dr, King's College London) — Principal investigator
First posted
Feb 16, 2017
Start date
Jan 30, 2013
Primary completion
May 30, 2017 (estimated)
Completion
Oct 30, 2018 (estimated)
Last update
Feb 17, 2017

Study contacts

Federico Foschi, Dr
Contact
federico.foschi@kcl.ac.uk
+44 (0)020 7188 7188
Dylan Herzog, Mr
Contact
dylan.b.herzog@kcl.ac.uk
+44 (0)207 188 1789
Federico Foschi, Dr
principal investigator · King's College London

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.

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Discussion

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