CClinicalTrials.gg
Status unknownNCT03029130Updated Jan 24, 2017

Catheter Extension Trial for Early Vesicovaginal Fistula Repair Failures

An interventional study of Catheter extension in Vesico Vaginal Fistula, sponsored by Evangel VVF Centre. Status unknown. Open to female participants. Per ClinicalTrials.gov, last updated 2017-01-24.

Sponsored by Evangel VVF Centre · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Jan 2017), so the status shown — last known as Enrolling by invitation — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
232
Allocation
Randomized
Sex
Female
01

Study summary

This study evaluates the use of extending time of continual urinary drainage (using transurethral foley catheter) for patients with early failures of vesicovaginal fistula repairs. Half of those included will be randomized to replacement of foley catheter for a length of 14 additional days, while the other half will be discharged (no intervention). Both groups will be examined for outcomes at 3 months post-repair.

Read the detailed description

At present, there is no standard of care nor consensus for the proper management of repaired vesicovaginal fistulas that begin leaking prior to or immediately after scheduled catheter removal. In the past, extension of time with catheterization has been tried, with patients becoming fully healed by the time of catheter removal. However, some patients who are discharged with a fistulous leak later return at follow up completely dry, with a closed and healed fistula. This study will compare, in a prospective, randomized manner, extension of catheterization vs no intervention, to see if in such patients extending catheterization will improve their likelihood of complete fistula healing.

02

Conditions studied

  • Vesico Vaginal Fistula

Browse trials for

Keywords

  • vesicovaginal fistula
  • urinary catheter
  • catheter extension
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Women who present with a vesicovaginal fistula for surgical repair AND who, at the time of initial catheter removal (7 or 14 days post-repair), have demonstrable fistulous leak on dye test

Exclusion criteria

Exclusion Criteria:

  • HIV infection,
  • concomitant bladder stone(s),
  • one or more ureters outside of the bladder,
  • urethrovaginal fistula,
  • multiple fistulas (more than one),
  • dye leak / fistulous leak present at end of surgical procedure,
  • radiation-induced fistula,
  • fistula caused by cancer or infection (such as lymphogranuloma venereum),
  • continence procedures being performed (such as pubovaginal sling),
  • rectovaginal fistula,
  • pregnancy,
  • fistula breakdown of greater than 2cm identified on postoperative dye test.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
232 participants (estimated)

Study arms

  • Experimental
    Catheter Extension

    Patients in this arm will have a foley catheter re-passed, to remain in situ for an additional 14 days, after which time the catheter will be removed and the patient discharged to return for follow up exam at 3 months postop.

    Device: Catheter extension

  • No intervention
    Discharge

    Patients in this arm will be discharged, to return for follow up exam at 3 months postop.

Interventions

  • DeviceCatheter extension

    Foley transurethral catheter placed to allow continuous drainage of urine.

05

What researchers measure

Primary outcomes

  1. Fistula closure

    Successful closure of the fistula, as defined by patient self-reporting no urinary leakage AND a negative dye test proving no fistulous leak

    Time frame: 3 months post-repair

Secondary outcomes

  1. Urinary continence

    Patient is completely continent of urine with no reported OR demonstrable leakage of dye on inspection.

    Time frame: 3 months post-repair

  2. Closure and continence at hospital discharge

    Rates of fistula closure and complete urinary continence at the time of hospital discharge

    Time frame: Date of discharge (7-28 days post-repair)

  3. Complications

    Rates of complications or urinary tract infections during hospitalization

    Time frame: Duration of hospitalization (minimum 7 days, maximum 28 days post-repair)

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03029130
Lead sponsor
Evangel VVF Centre
Responsible party
Steven Shephard (Fistula Surgeon, Evangel VVF Centre) — Principal investigator
First posted
Jan 24, 2017
Start date
Jan 1, 2017
Primary completion
Dec 31, 2019 (estimated)
Completion
Mar 31, 2020 (estimated)
Last update
Jan 24, 2017

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion