Vorinostat in Patients With Class 2 High Risk Uveal Melanoma

1. Uveal melanoma tumor determined by ophthalmic ultrasound or clinical assessment.
2. Class 2 uveal melanoma
3. No evidence of metastatic disease.
4. Age ≥18 years.
5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
6. Life expectancy of greater than 3 months.
7. Able to swallow and retain orally-administered medication and does not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels

8. Patients must have normal organ and marrow function as defined below:

   • Absolute neutrophil count (ANC) >1,500 cells/mm³
   • Platelet count >100,000/mm³
   • Hemoglobin >10.0g/dL
   • Aspartate transaminase (AST) and/or Alanine transaminase (ALT) \< 3x upper limited of normal (ULN)
   • Total bilirubin \< 2x ULN
   • Hemoglobin A1C ≤ 5.7%
   • Alkaline phosphatase \< 3x ULN
   • Serum creatinine \< 2x ULN or a creatinine clearance > 60 mL/min
   • Note: Patients with hyperbilirubinemia clinically consistent with an inherited disorder of bilirubin metabolism (e.g., Gilbert syndrome) will be eligible at the discretion of the treating physician and/or the principal investigator.
9. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation until 4 months after completion of study drug administration. Women of child-bearing potential must have a negative serum or urine test at time of enrollment. Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study therapy, and 4 months after completion of study drug administration.
10. Willingness to comply with all the visits and procedures (including providing all biological specimens) as required by the protocol and the informed consent form (ICF).
11. Ability to understand the investigational nature, potential risks and benefits of the research study and to provide valid written informed consent.

Exclusion Criteria:

1. Definitive therapy of the primary uveal melanoma by either surgery or radiotherapy
2. History of another malignancy except for those who have been disease-free for 3 years, or patients with a history of completely resected non-melanoma skin cancer and/or patients with indolent secondary malignancies not requiring active therapy, are eligible. Consult the study Principal Investigator if unsure whether second malignancies meet the requirements specified above.
3. Any major surgery or extensive radiotherapy, chemotherapy with delayed toxicity, biologic therapy, or immunotherapy within 21 days prior to initiation of study therapy.
4. History of prior vorinostat use.
5. Use of other investigational drugs within 28 days
6. Have a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to vorinostat (i.e. HDAC inhibitor hydroxamates such as panobinostat and belinostat).
7. A QT interval corrected (QTc) for heart rate using the Bazett's formula (QTcB) ≥ 480 msec. Concurrent administration of vorinostat and agents that can cause QTc prolongation is not permitted.
8. Concurrent administration of vorinostat and other HDAC inhibitors is not permitted due to the increased risk of thrombocytopenia and gastrointestinal bleeding.
9. Patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with vorinostat.
10. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infections, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with the study requirements.
11. History of pulmonary embolism (PT) or deep-vein thrombosis (DVT)