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WithdrawnNCT03014284Updated Sep 17, 2018

Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

An observational study in Colon Cancer and Colitis, sponsored by The University of Texas Health Science Center at San Antonio. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-09-17.

Sponsored by The University of Texas Health Science Center at San Antonio · Observational

Why this study was withdrawn
Military collaborator sample supplier was transferred, no samples obtained
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
0
Ages
18 Years to 100 Years
Sex
All
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Study summary

This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.

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Conditions studied

  • Colon Cancer
  • Colitis

Keywords

  • Tissue collection
  • colonoscopic surgical procedures
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In context

Colonic Neoplasms

1,432 studies on the registry are indexed under Colonic Neoplasms; 357 are open to participants now.

Browse Colonic Neoplasms studies →

Lead sponsor

The University of Texas Health Science Center at San Antonio is the lead sponsor of 435 studies on the registry; 88 are open to participants now.

Of its 62 completed or terminated interventional studies of FDA-regulated products, 31 (50%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Approximately 50% of patients are expected to be Caucasian, about 40% Hispanic and the remainder African American and other minorities. The investigators anticipate that subjects will range in age from 18 years old and older.

Inclusion criteria

  • Able to provide informed consent (or have consent provided through a guardian)
  • No immune-modulating drug use during study or within 30 days prior to enrollment
  • Having colon material collected as part of standard of care

Exclusion criteria

Exclusion Criteria:

  • Unable to provide informed consent (or have consent provided through a guardian)
  • Not having colon material collected as part of standard of care
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
0 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna
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What researchers measure

Primary outcomes

  1. Expression of B7-H1

    To assess the ability of recombinant Listeria to modulate B7-H1 in human colonic tissues

    Time frame: Baseline tissue collection

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Study locations

1 site
  • Cancer Therapy & Research Center at UTHSCSA
    San Antonio, Texas 78229, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 17, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03014284
Lead sponsor
The University of Texas Health Science Center at San Antonio
Responsible party
Sponsor
First posted
Jan 9, 2017
Start date
Jan 20, 2017
Primary completion
Sep 12, 2018
Completion
Sep 12, 2018
Last update
Sep 17, 2018

Study contacts

Tyler Curiel, MD
principal investigator · University of Texas Health Science Center at the Cancer Therapy and Research Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.

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