An interventional study of Upper Extremity Aerobic Exercise in Hematopoietic Stem Cell Transplantation and Aerobic Exercise, sponsored by Gazi University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2021-02-25.
Sponsored by Gazi University · Not applicable, Interventional, and Supportive care
Hematologic malignancy is a tumor of myeloid or lymphatic cells that affects lymph nodes with the involvement of blood, bone marrow or other organs.There are various treatment options for hematological malignancies ranging from follow-up to single or multiple agent chemotherapy, radiotherapy, immunotherapy and autologous or allogeneic hematopoietic stem cell transplantations (HSCT). The general recommendation for patients is to relax and avoid intense exercise, regardless of the devastating consequences of neglecting physical exercise. Patients also go to relaxation by reducing their activity to avoid fatigue, which leads to loss of muscle strength and endurance. As a consequence of all, fatigue, vomiting, weight loss, anemia, depression, decreased aerobic capacity, muscle weakness, decreased physical function and poor quality of life are observed in HSCT recipients. It has been shown that physical exercises improve oxygen consumption, depression and fatigue, cardiorespiratory fitness, muscle strength and physical well-being in patients with hematologic malignancies who are at stages of various treatments. In literature, effects of upper extremity aerobic exercise training have been investigated in patients with spinal cord injury, neuromuscular diseases, claudication, hypertension, multiple sclerosis, heart failure, paraplegic patients and healthy individuals. Results of these studies has shown that upper extremity aerobic exercise training improves walking distance, increases oxygen pulse, muscle strength and endurance of upper extremity. No study was observed to investigate the effects of upper extremity aerobic exercise training on exercise capacity and quality of life in HSCT recipients, as we know. For this reason, our aim is to investigate the effects of upper extremity aerobic exercise training on exercise capacity and quality of life in HSCT recipients.
Minimum 30 allogeneic and autologous HSCT recipients (˃100 days past post-transplant status) will be included. Before and after 6-week upper extremity aerobic exercise training, maximal and submaximal exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, physical activity, dyspnea and fatigue perception, anxiety, depression and quality of life were evaluated. Primary outcome measurements were exercise capacity and quality of life , secondary outcomes were respiratory and peripheral muscle strength, pulmonary functions, physical activity, dyspnea and fatigue perception, anxiety and depression.
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Exclusion Criteria:
The upper extremity aerobic exercise training with an arm ergometer will be performed in the treatment group so that training intensity will be between 60% and 80% of the maximum heart rate, dyspnea perception will be 3-4 according to Modified Borg Scale and fatigue perception will be 5-6 according to Modified Borg Scale, training duration will be a 6-week.
Other: Upper Extremity Aerobic Exercise
Deep breathing exercises combinated with arm movements will be given as a home schedule in the control group. Training duration will be a 6-week.
Range of maximal heart rate is being followed by a polar band during supervised session each week. Aerobic exercise is being trained for 30 min-per/day, 3 days/week, 6 weeks. All sessions are being performed by a physiotherapist at cardiopulmonary rehabilitation department.
functional exercise capacity evaluation
Evaluated with 6-minute walking test
Time frame: 6-week
pulmonary functions test
Evaluated with spirometer
Time frame: 6-week
muscle strength
Evaluated with a hand-held dynamometer for peripheral muscles, mouth pressure device for respiratory muscle strength
Time frame: 6-week
cough strength
Evaluated with peak flow meter
Time frame: 6-week
physical activity level
Evaluated with a metabolic holter
Time frame: 6-week
fatigue severity
Evaluated using Fatigue Severity Scale
Time frame: 6-week
anxiety and depression perception
Evaluated using Hospital Anxiety and Depression Scale
Time frame: 6-week
dyspnea perception
Evaluated using Modified Medical Research Council Dyspnea scale (MMRC) and Modified Borg Scale
Time frame: 6-week
quality of life level
evaluated using QOL using European Organization for Research and Treatment of Cancer QOL Questionnaire (EORTCQOL)
Time frame: 6-week
maximal exercise capacity evaluation
evaluated using Modified Incremental Shuttle Walk Test
Time frame: 6-week
Plan to share: No — There is not a plan to make individual participant data but when the statistical analyses of all data are made, all results will be shared.
This study is completed, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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Gazi University