An interventional study of Reduced Sedentary Time Intervention (RSTI) in Breast Cancer, sponsored by Baystate Medical Center. Completed at 1 site in United States. Open to female participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2019-07-17.
Sponsored by Baystate Medical Center · Not applicable, Interventional, and Treatment
There is a well-documented association between physical activity \& risk for breast cancer development and recurrence. It is known that exercise interventions have been effective at increasing physical activity levels in breast cancer survivors. Knowing that breast cancer survivors are less active than non-cancer patients, a less active lifestyle places them at risk of obesity and poor overall health, which in turn also increases risk of cancer and cancer recurrence. Not all the reasons for the risk reduction are clear, however it is known that hormones and other inflammatory markers play a role.
This study has three goals:
There is a well-documented association between physical activity and risk for breast cancer development and recurrence. Exercise training interventions have been effective at increasing physical activity levels in breast cancer survivors, however they require 1) a large degree of patient initiative to achieve positive health outcomes associated with sustained behavioral change and 2) facilities and oversight that may be prohibitive in a clinical setting. Although most activity-based research to date has focused on increasing levels of moderate to vigorous physical activity (MVPA) for breast cancer survivors, large epidemiological studies suggest that breast cancer survivors are also more sedentary when compared to non-cancer controls. A recent meta-analysis of controlled intervention trials designed to promote physical activity among sedentary cancer survivors found that none of the trials within the scope of the review succeeded in achieving 75% or better adherence to prescribed exercise guidelines, leading the authors to question whether shifting the target of intervention from MVPA to reductions in sedentary time might be a more realistic goal. Recent research suggests that interventions designed to reduce sedentary time in breast cancer survivors have the potential to yield clinically meaningful health benefits, especially for individuals at higher risk for sedentary behaviors, however the optimal method of intervention is not clear.
Aim 1: Feasibility of the intervention Assess the feasibility of an intervention designed to reduce sedentary behavior in breast cancer survivors. The behavioral intervention will involve the review of a 7-day baseline snapshot of sedentary behavior and physical activity patterns, combined with tailored activity prompts described over the following 6 weeks.
Aim 2: Effects of the intervention Aim 2a: Describe a preliminary range of effect sizes of the intervention on levels of sedentary behavior, physical activity and symptoms of cancer survivorship (e.g. cancer related fatigue).
Aim 2b: Evaluate the relationship between change in sedentary behavior and change in cancer-relevant outcomes, such as fatigue and biomarkers of cancer recurrence (e.g. IGF-1, Leptin), following the reduced sedentary time intervention.
Aim 3: Assessment of intervention components Aim 3a: Quantitatively assess overall cost of the intervention and its individual components, dose delivered and dose received by intervention participants Aim 3b: Quantitatively describe intervention participants' perspectives on the impact of the individual intervention components, including which components appeared most useful for reducing sedentary time.
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's enrollment of 13 is below the median of 72 across 9,302 interventional studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Baystate Medical Center is the lead sponsor of 47 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Reduced Sedentary Time Intervention (RSTI)
Behavioral: Reduced Sedentary Time Intervention (RSTI)
Following 7 days of baseline activity monitoring a study investigator will download the information from the monitor, evaluate the periods of sedentary behavior and create a tailored RSTI for each participant. For example, the investigator may notice a long stretch of sitting in the evening following a meal and identify several exercises that can be done indoors during that time, or if the participant is amiable to walking breaks and a period after work is identified the investigator might suggest the appropriate walking activity at that time. This program has been successful in sedentary overweight office workers and investigators will use similar techniques.
Sedentary Time
Change in minutes/day of sedentary time as recorded by ActivPal in all 25 participants pre and post intervention.
Time frame: 8 weeks
Activity Level
Change in Activity level as recorded by Actigraph monitor in all 25 participants
Time frame: 8 weeks
Glucose
Change in fasting glucose ( mmol/L)in all 25 participants
Time frame: 8 weeks
Insulin
Change in insulin (pmol/L) in all 25 participants
Time frame: 8 weeks
Total cholesterol
Change in total cholesterol (mmol) in all 25 participants
Time frame: 8 weeks
High density lipoprotien cholesterol
Change in high density lipoprotein cholesterol (mmol) in all 25 participants
Time frame: 8 weeks
Triglyceride
Change in triglycerides (mmol) in all 25 participants
Time frame: 8 weeks
Body Mass Index
Change in Body Mass Index (kg/m2) in all 25 participants
Time frame: 8 weeks
Waist Circumference
Change in waist circumference in cm in all 25 participants
Time frame: 8 weeks
Systolic Blood pressure
Change in systolic blood pressure measured in mmHg in all 25 participants
Time frame: 8 weeks
Diastolic Blood pressure
Change in diastolic blood pressure measured in mmHg in all 25 participants
Time frame: 8 weeks
Cancer-related fatigue measured by change in PROMIS short form 8a in all 25 participants
Time frame: 8 weeks
Cancer-related fatigue as measured by change in Visual Analog scale in all 25 participants
Time frame: 8 weeks
Sedentary behavior self -efficacy
Change in Sedentary Behavior Self-Efficacy Scale (modified from BARSE) in all 25 participants
Time frame: 8 weeks
Change in EORTC-QLQ-C30 scores in all 25 participants
Time frame: 8 weeks
Assessment of Intervention
Change in Assessment of Intervention questions on a scale of 1-5 in all 25 participants
Time frame: 8 weeks
Plan to share: Undecided
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This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Baystate Medical Center