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CompletedNCT02963298GCRRTUpdated Jun 21, 2019

CRRT for Glutamate Elimination After Cardiac Arrest

An interventional study of Continuous renal replacement therapy in Reperfusion Syndrome, sponsored by C. Storm. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-06-21.

Sponsored by C. Storm · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
42
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.

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Conditions studied

  • Reperfusion Syndrome

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03

In context

Heart Arrest

966 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.

This study's enrollment of 42 is below the median of 100 across 557 interventional studies indexed under Heart Arrest.

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Lead sponsor

This is the only study on the registry with C. Storm as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • post cardiac arrest

Exclusion criteria

Exclusion Criteria:

  • hemodynamic instable
  • in-hospital cardiac arrest
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
42 participants (actual)

Study arms

  • Active comparator
    CRRT after cardiac arrest

    Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels.

    Procedure: Continuous renal replacement therapy

  • No intervention
    control

    Repetitive testing of blood Glutamate levels without CRRT

Interventions

  • ProcedureContinuous renal replacement therapy
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What researchers measure

Primary outcomes

  1. Glutamate blood concentration in intervention arm over the time

    Reduction of blood Glutamate concentration by renal replacement therapy

    Time frame: 72 hours

Secondary outcomes

  1. number of participants with abnormal outcome parameters

    Time frame: up to 14 days

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Study locations

1 site
  • Charité-Universitätsmedizin Berlin
    Berlin, 13353, Germany
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References and documents

Publications

  • Nee J, Jorres A, Krannich A, Leithner C, Schroeder T, Munk AL, Enghard P, Moore C, Steppan S, Storm C. Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial. Resuscitation. 2019 Nov;144:54-59. doi: 10.1016/j.resuscitation.2019.09.020. Epub 2019 Sep 23. PubMed 31557520 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 21, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02963298
Lead sponsor
C. Storm
Responsible party
C. Storm (PD Dr. med., Charite University, Berlin, Germany) — Sponsor-investigator
First posted
Nov 15, 2016
Start date
Oct 2016
Primary completion
Sep 6, 2017
Completion
Sep 6, 2017
Last update
Jun 21, 2019

Study contacts

Christian Storm, MD
principal investigator · Charite University, Berlin, Germany

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2019. You cannot join it, but the record below documents what was studied.

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