Combination Radiation and PD-1 Inhibition in Metastatic or Recurrent Renal Cell Carcinoma (RCC)

1. Histologically confirmed history of renal cell carcinoma (all variants are acceptable)
2. Progression or recurrence after at least one prior tyrosine kinase inhibitor therapy including, but not limited to: sunitinib, pazopanib, axitinib.

3. At least 1 site (primary or metastasis) amenable to hypofractionated radiation therapy and appropriate for radiation therapy as part of standard of care per medical, urologic or radiation oncologist discretion. NOTE: CT / MRI imaging to have been completed no more than 30 days before enrollment on study.

   Potential indications for radiation therapy include (but are not limited to):

   • Painful bone or soft tissue metastasis
   • Symptoms from mass effect caused by tumor
   • Prevention of impending symptoms from tumor
   • Hemoptysis due to tumor
   • Limited oligometastasis
   • Isolated region of progression
4. Patients with prior IL-2 treatment are eligible
5. At least 14 days since any prior therapy
6. Eastern Cooperative Oncology Group (ECOG) performance status 0 - 3

7. Adequate organ and marrow function as defined below:

   • leukocytes ≥ 2,000/mcL
   • absolute neutrophil count ≥ 1,000/mcL
   • platelets ≥ 100,000/mcL
   • total bilirubin within normal institutional limits
   • AST(SGOT) ≤ 2.5 X institutional upper limit of normal
   • ALT(SPGT) ≤ 2.5 X institutional upper limit of normal
8. Women of child-bearing potential and men with partners of child-bearing potential must agree to use adequate contraception. Men of child-bearing potential must not donate sperm while on this study and for 90 days after their last study treatment.

Exclusion Criteria:

1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
2. Men who are trying to father a child.
3. Presence of a condition or abnormality that in the opinion of the study-delegated investigator would compromise the safety of the patient or the quality of the data.

4. Requirement for high dose steroids: dexamethasone > 2 mg per day or equivalent

   • NOTE: Per OPDIVO (Nivolumab) package insert, no formal pharmacokinetic drug-drug interaction studies have been conducted with OPDIVO (Nivolumab) - therefore, no other concomitant medications will exclude potential participants.
5. Life expectancy \< 6 months.
6. Other active malignancy (patients with no evidence of disease (NED) or are in remission are eligible).
7. Patient has untreated brain metastases. Patients are eligible after documented stable or improved brain metastases at least 1 month after treatment of brain metastases.
8. History of allergic reactions attributed to compounds of similar chemical or biologic composition to PD-1 Inhibitors used in study.
9. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
10. Patients with active, known or suspected autoimmune disease (not including type 1 diabetes mellitus, hypothyroidism, skin disorders not requiring systemic treatment or conditions not expected to recur).
11. Patients with interstitial lung disease
12. Patients receiving concurrent other cancer-directed therapy including, but not limited to, Tyrosine Kinase Inhibitor (TKI), Mammalian Target Of Rapamycin (mTOR) inhibition and/or chemotherapy.