CClinicalTrials.gg
CompletedNCT02928939Updated Apr 8, 2021

Therapeutic Conflicts and Multimorbidity

An observational study in Gastrointestinal Hemorrhage, Diabetes Complications and Multimorbidity, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-04-08.

Sponsored by University of Zurich · Observational

Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
1,101
Ages
18 Years and older
Sex
All
01

Study summary

Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.

Read the detailed description

The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.

02

Conditions studied

  • Gastrointestinal Hemorrhage
  • Diabetes Complications
  • Multimorbidity

Keywords

  • multimorbidity
  • multiple chronic conditions
  • drug-drug interactions
  • drug-disease interactions
  • polypharmacy
  • Oral anticoagulants
  • Steroids
03

In context

Gastrointestinal Hemorrhage

339 studies on the registry are indexed under Gastrointestinal Hemorrhage; 79 are open to participants now.

This study's enrollment of 1,101 is above the median of 200 across 116 observational studies indexed under Gastrointestinal Hemorrhage.

Browse Gastrointestinal Hemorrhage studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

We investigate in the field of multimorbidity in a tertiary hospital regarding therapeutic conflicts of GI bleeding and diabetes exacerbation.

Inclusion criteria

  • Inpatients at the University Hospital Zurich, USZ
  • Male and female patients, aged 18 years or older
  • Fulfilling the criteria for Use Case A or B (i.e. patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs, Use Case A or patients with diabetes mellitus and/or systemic corticosteroids, Use Case B)

Exclusion criteria

Exclusion Criteria:

  • If potential participants have a statement in the electronic medical record or elsewhere to refuse study participation, this represents exclusion criteria.
05

Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
1,101 participants (actual)
Patient registry
No

Groups and cohorts

  • Multimorbid patients

    Other: drug-drug or drug-disease interaction

Interventions

  • Otherdrug-drug or drug-disease interaction
06

What researchers measure

Primary outcomes

  1. Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs

    Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding?

    Time frame: 5 years

  2. Patients with diabetes mellitus and systemic corticosteroids

    Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus?

    Time frame: 5 years

07

Study locations

1 site
  • University Hospital Zurich
    Zurich, Switzerland
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 8, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02928939
Lead sponsor
University of Zurich
Collaborators
University Hospital, Zürich, Center of Competence Multimorbidity, Zurich
Responsible party
Sponsor
First posted
Oct 10, 2016
Start date
Oct 2016
Primary completion
Aug 2020
Completion
Apr 2021
Last update
Apr 8, 2021

Study contacts

Edouard Battegay, Prof. MD
study director · University Hospital Zurich, Department of Internal Medicine
Klarissa Siebenhüner, MD
principal investigator · University Hospital Zurich, Department of Internal Medicine
Patrick Beeler, MD
study chair · University Hospital Zurich, Department of Internal Medicine

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion