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CompletedNCT02928341Updated Aug 26, 2022

Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo

An interventional study of Improved water supply in Cholera and Diarrhea, sponsored by London School of Hygiene and Tropical Medicine. Completed at 1 site in Congo, The Democratic Republic of the. Per ClinicalTrials.gov, last updated 2022-08-26.

Sponsored by London School of Hygiene and Tropical Medicine · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
4,556
Allocation
Randomized
Sex
All
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Study summary

The aim of the study is to evaluate the impact of a large-scale urban water supply improvement intervention on cholera and other diarrhoeal diseases. The study uses a step wedge cluster randomised controlled trial (SWcRCT) to measure the effect of the intervention on cholera centre admission rates and confirmed cholera cases. A nested cohort study will examine changes in water-related practices following the intervention.

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Conditions studied

  • Cholera
  • Diarrhea

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In context

Cholera

83 studies on the registry are indexed under Cholera; 16 are open to participants now.

This study's enrollment of 4,556 is above the median of 262 across 72 interventional studies indexed under Cholera.

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Lead sponsor

London School of Hygiene and Tropical Medicine is the lead sponsor of 298 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Uvira resident admitted to the Uvira Cholera Treatment Centre in Uvira

Exclusion criteria

Exclusion Criteria:

  • Any patients admitted during the period of intervention implementation in each cluster
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Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
4,556 participants (actual)

Study arms

  • No intervention
    No intervention

    Current water supply access

  • Experimental
    Intervention

    Received water supply improvement intervention designed to improve access to tap water, consisting of community managed public taps, improved tap water distribution network, refurbished tap connections and promotion of new household tap connections.

    Other: Improved water supply

Interventions

  • OtherImproved water supply
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What researchers measure

Primary outcomes

  1. Admission rate to the Uvira Cholera Treatment Centre

    Time frame: 36 months

Secondary outcomes

  1. Admission rate to the Uvira Cholera Treatment Centre of laboratory confirmed cholera cases

    Time frame: 36 months

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Study locations

1 site
  • Centre de Traitement du Cholera, Hôpital General de Reference d'Uvira, Sud-Kivu, République Démocratique du Congo
    Uvira, Sud-Kivu, Congo, The Democratic Republic of the
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References and documents

Publications

  • Gallandat K, Jeandron A, Ross I, Mufitini Saidi J, Bashige Rumedeka B, Lumami Kapepula V, Cousens S, Allen E, MacDougall A, Cumming O. The impact of improved water supply on cholera and diarrhoeal diseases in Uvira, Democratic Republic of the Congo: a protocol for a pragmatic stepped-wedge cluster randomised trial and economic evaluation. Trials. 2021 Jun 21;22(1):408. doi: 10.1186/s13063-021-05249-x. PubMed 34154636 ↗
  • Williams C, Cumming O, Grignard L, Rumedeka BB, Saidi JM, Grint D, Drakeley C, Jeandron A. Prevalence and diversity of enteric pathogens among cholera treatment centre patients with acute diarrhea in Uvira, Democratic Republic of Congo. BMC Infect Dis. 2020 Oct 9;20(1):741. doi: 10.1186/s12879-020-05454-0. PubMed 33036564 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 26, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02928341
Responsible party
Sponsor
First posted
Oct 10, 2016
Start date
Oct 2016
Primary completion
Dec 31, 2021
Completion
Dec 31, 2021
Last update
Aug 26, 2022

Study contacts

Oliver Cumming, MSc
principal investigator · London School of Hygiene and Tropical Medicine
Karin Gallandat, PhD
principal investigator · London School of Hygiene and Tropical Medicine

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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