An observational study in Narcolepsy and Cataplexy, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-25.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Observational
Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia. Drug-free patients diagnosed with idiopathic hypersomnia and age-matched controls were included. Clinical data, 24-h polysomnography, heart rate variability and the heart rate response to spontaneous arousal are analyzed.
152 studies on the registry are indexed under Narcolepsy; 32 are open to participants now.
This study's enrollment of 33 is below the median of 120 across 36 observational studies indexed under Narcolepsy.
Browse Narcolepsy studies →Centre Hospitalier Universitaire de Saint Etienne is the lead sponsor of 597 studies on the registry; 127 are open to participants now.
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Idiopathic hypersomnia patients and no idiopathic hypersomnia patient
Inclusion Criteria:
Idiopathic hypersomnia patients
Inclusion Criteria:
no idiopathic hypersomnia patients
Exclusion Criteria (both):
Drug-free patients diagnosed with idiopathic hypersomnia from 01/01/11 to 15/09/15
Device: Polysomnography
Patients with no sleep complaints, having a 24-h ambulatory ad libitum polysomnography
Device: Polysomnography
The polysomnography, for both groups, was performed accordance with standard practice
High Frequencies (HF)
Nocturnal parasympathetic activity (HF parameter of heart rate variability analysis)
Time frame: During the polysomnography (one night)
Heart rate variability (HRV)
HRV is measured by the polysomnography. It is a composite outcome : Standard Deviation of NN intervals (SDNN), the proportion of NN30 (and 50) divided by total number of NNs (pNN30, pNN50), Root Mean Square of Successive Differences (RMSSD), Standard Deviation type 1 and 2 (SD1, SD2), Low Frequencies (LF), Very Low Frequencies (VLF), LF/HF ratio and Ptot indexes
Time frame: During the polysomnography (one night)
Apnea-Hypopnea Index (AIH)
Time frame: During the polysomnography (one night)
Epworth Sleepiness Scale (ESS)
It examines eight different situations using a 4-grade scale ranging from 0 (no chances of napping) to 3 (high chances of napping). Subjects were defined as sleepy if they had an ESS\>10
Time frame: Before the polysomnography (one night)
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.
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