An interventional study of Therapeutic Plasma Exchange (TPE) in Multiple Organ Failure, sponsored by University of Rostock. Status unknown at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-04-07.
Sponsored by University of Rostock · Not applicable, Interventional, and Treatment
Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.
Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study.
Investigators will study three groups:
All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma. The study will focusing on the organ functions of the patients, especially liver-, kidney- and nervous function and also displayed in the SOFA score on study days 3 and 7.
156 studies on the registry are indexed under Multiple Organ Failure; 44 are open to participants now.
This study's planned enrollment of 30 is below the median of 75 across 75 interventional studies indexed under Multiple Organ Failure.
Browse Multiple Organ Failure studies →University of Rostock is the lead sponsor of 46 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients with septic shock, no therapeutic plasma exchange, BMC standard treatment
Patients with septic shock, therapeutic plasma exchange, plasma separation using a filter (Fresenius MultiFiltrate, Kit 16 MPS P2 dry), BMC standard treatment
Device: Therapeutic Plasma Exchange (TPE)
Patients with septic shock, therapeutic plasma exchange, plasma separation using a centrifuge (Fresenius COM-TEC, PL1 Erythrozytapherese/Plasmabeutel Set) BMC standard treatment
Device: Therapeutic Plasma Exchange (TPE)
All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma.
SOFA score ≥ 2 Punkte
SOFA: Sepsis-related Organ Failure Assessment score
Time frame: day 3
SOFA score ≥ 2 Punkte
SOFA: Sepsis-related Organ Failure Assessment score
Time frame: day 7
28-day survival
Observation time 28 days
Time frame: day 28
Hospital survival
Leave the patients the hospital?
Time frame: 1 year
number of thrombocytes (DIC)
values of thrombocytes, screening for DIC
Time frame: days 1-7, 14, 21, 28
Haptoglobulin values
values haptoglobulin, screening for hemolysis
Time frame: days 1-7, 14, 21, 28
Plan to share: No — No.
No publications or documents are linked to this record.
This study is status unknown, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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University of Rostock