An observational study in Asthma, Children and Obesity, sponsored by Pontificia Universidad Catolica de Chile. Completed. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2021-09-10.
Sponsored by Pontificia Universidad Catolica de Chile · Observational
This study seeks a better understanding of the pathogenesis of asthma in early life. The aim of this project is to determine whether the offspring of obese mothers at 3 years of life have increased the risk of asthma compared to children whose mothers were not obese and whether this increased risk is associated with a programming altered immune reactivity at birth.
The general objectives of this study are:
The study is performed in accordance with the Helsinki Declaration, and the study protocol was accepted by Institutional Review Boards at School of Medicine of the Pontificia Universidad Católica de Chile.
3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.
This study's enrollment of 240 is above the median of 150 across 970 observational studies indexed under Asthma.
Browse Asthma studies →Pontificia Universidad Catolica de Chile is the lead sponsor of 215 studies on the registry; 56 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The recruitment of participants was performed in the Sotero del Rio Hospital at Santiago. Women that were obese (BMI>30) or normal weight (BMI\<25) at their first antenatal visit were invited to participate in the study at the moment of delivery.
Questionnaires: Information regarding birth outcomes, maternal and paternal history of asthma and allergy, as well as environmental conditions at home (pet ownership, indoor smoking, heating system, and so on) was collected using a questionnaire at the moment of recruitment.
Follow-up questionnaires by phone are completed every 6 months. These questionnaires collect information regarding diagnosis of asthma/allergy and acute respiratory illness, environmental conditions, and relevant confounding variables
Exclusion Criteria:
Obese (BMI\>30) or normal weight (BMI\<25) women at their first antenatal visit were invited to participate in the study at the moment of delivery at Sotero del Rio Hospital, Santiago. Information regarding birth outcomes, parental history, as well as environmental conditions was collected at recruitment. Follow-up questionnaires by phone were completed every 6 months. Umbilical cord blood samples were collected to measure IL-12, TNF-α, IL-10, IL-4; to evaluate metabolic status; to isolated monocytes and macrophage differentiation; and for DNA methylation status of the promoter regions of the genes coding for TNF-α, IL-12, IL-10, and IL-4Rα. Also, fasting blood samples of the mothers within 48 hours after delivery; and blood samples and skin prick test were collected.
Risk of asthma (defined as "positive asthma predictive index" at 36 months of age)
Time frame: 36 months of age
Allergy status (positive skin prick test)
Time frame: 30-36 months of age
No study locations are listed for this record.
Plan to share: No
This study is completed, as verified in Jun 2018. You cannot join it, but the record below documents what was studied.
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Pontificia Universidad Catolica de Chile