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Status unknownNCT02893436DBS PREDICTIONUpdated Sep 8, 2016

Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation

An observational study in Anesthesia and Surgery, sponsored by Central Hospital, Nancy, France. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-09-08.

Sponsored by Central Hospital, Nancy, France · Observational

The sponsor has not verified this record recently (last verified Aug 2016), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
50
Ages
18 Years and older
Sex
All
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Study summary

The purpose is to calculate the time for an optimal recovery (T4/T1 > 0.9) from the moment when 2 responses to double burst stimulation are visually identical and this for 95% of patients.

Read the detailed description

Neuromuscular monitoring is a basic monitoring for all curarised patients. Acceleromiography is used to supervise neuromuscular blockade and allow measuring in an objective and quantitative manner the curarisation level during surgery and phase of recovery from neuromuscular blockade. Various parameters are usually measured during surgery:

  • T4/T1 ratio: ratio between the 4th and 1st response to "train of four" stimulation (TOF, 4 stimulations of 0.2 ms in 2 s). Neuromuscular recovery is considered appropriate if T4/T1 ratio is > 0.9
  • Double burst stimulation (DBS): 2 short tetanic stimulations separated by an interval of 750 ms.

It is known that when DBSs induce the same visual and/or tactile response, T4/T1 recovery time is > 0.6. However, for an optimal recovery, T4/T1 ratio must be > 0.9.

This study will analyze the interval between the moment when DBSs are visually identical and the T4/T1 ratio is > 0.9, from anesthesia sheet of patients undergone surgery with tracheal intubation curarisation.

Results will define a minimum time to have an optimal recovery after having visually identical DBS responses.

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Conditions studied

  • Anesthesia
  • Surgery
03

In context

Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 778 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patient curarised at Nancy Hospital

Inclusion criteria

  • ASA score 1-3
  • Needing a surgery with tracheal intubation curarisation

Exclusion criteria

Exclusion Criteria:

  • none
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Groups and cohorts

  • Curarized patients

    Procedure: Surgery with tracheal intubation curarisation

Interventions

  • ProcedureSurgery with tracheal intubation curarisation
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What researchers measure

Primary outcomes

  1. Time interval between the moment when DBSs are visually identical and the T4/T1 ratio is > 0.9

    measured with TOF-Watch Sx

    Time frame: day 0

07

Study locations

1 of 1 sites recruiting
  • CHRU Nancy
    Vandoeuvre Les Nancy, France
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 8, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02893436
Lead sponsor
Central Hospital, Nancy, France
Responsible party
Sponsor
First posted
Sep 8, 2016
Start date
Apr 2014
Primary completion
Sep 2016 (estimated)
Completion
Sep 2016 (estimated)
Last update
Sep 8, 2016

Study contacts

Denis Schmartz
Contact
d.schmartz@chru-nancu.fr
Denis Schmartz
principal investigator · CHRU Nancy, France

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.

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