Status unknownNCT02885584Updated Aug 31, 2016

Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients

An interventional study of High frequency percussive ventilation in ARDS, sponsored by Assistance Publique Hopitaux De Marseille. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-08-31.

Sponsored by Assistance Publique Hopitaux De Marseille · Not applicable, Interventional, and Supportive care

The sponsor has not verified this record recently (last verified Aug 2016), so the status shown — last known as Active, not recruiting — may be out of date.

Phase: Not applicable
Study type: Interventional
Enrollment: 30
Allocation: Randomized
Ages: 18 Years and older
Sex: All

Study summary

High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan

Conditions studied

ARDS

Keywords

Mechanical ventilation

In context

Lead sponsor

Assistance Publique Hopitaux De Marseille is the lead sponsor of 686 studies on the registry; 148 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years and older
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

Patient undergoing invasive ventilation for more than 24h
ARDS patient

Exclusion criteria

Exclusion Criteria:

Pneumothorax drained or not
Patient undergoing extracorporel mechanical oxygenation
Patient who had a pneumonectomy partiel or total

Study design

Phase: Not applicable
Primary purpose: Supportive care
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Single (Participant)
Enrollment: 30 participants (estimated)

Study arms

Experimental
Transpulmonary pressure controlled mechanical ventilation
transpulmonary pressure will be used for ventilation settings
Device: High frequency percussive ventilation
No intervention
Conventional pressure-controlled mechanical ventilation
transpulmonary pressure will not be used for ventilation settings

Interventions

DeviceHigh frequency percussive ventilation

What researchers measure

Primary outcomes

Percent of patients exhibiting under HFPV an increase of at least 15% of normally aerated end-expiratory lung volume
Time frame: 4 hours

Study locations

1 site

Assistance Publique-Hôpitaux de Marseille
Marseille, 13354, France

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Aug 31, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02885584
Lead sponsor: Assistance Publique Hopitaux De Marseille
Responsible party: Sponsor
First posted: Aug 31, 2016
Start date: Dec 2013
Primary completion: May 2016
Completion: May 2017 (estimated)
Last update: Aug 31, 2016

Study contacts

Urielle DESALBRES

study director · Assistance Publique-Hôpitaux de Marseille

Antoine ROCH, MD/PhD

principal investigator · Assistance Publique-Hôpitaux de Marseille

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.

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