An observational study in Chromosome Abnormalities, Genetic Diseases, Inborn and Mutation, sponsored by Al Baraka Fertility Hospital. Completed. Open to participants aged 20 Years to 45 Years. Per ClinicalTrials.gov, last updated 2021-08-19.
Sponsored by Al Baraka Fertility Hospital · Observational
In the way for developing and optimizing protocol to be used as non- invasive methodology used as routine testing for PGS.
This protocol is to be adapted to replace the using of life embryo cells for genetic testing and aneuploidy study as well as for any type of genetic testing including single gene disorder or HLA typing or study.
Compare 100 embryos studied using NGS for chromosomal aneuploidies, and compare the results came from free media DNA with this results.
48 studies on the registry are indexed under Chromosome Aberrations; 10 are open to participants now.
This study's enrollment of 100 is below the median of 231 across 30 observational studies indexed under Chromosome Aberrations.
Browse Chromosome Aberrations studies →Al Baraka Fertility Hospital is the lead sponsor of 8 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Embryos arranged for PGS study
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Biopsy and archival tissue
A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.
Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Ability to read the DNA product available in embryo culture media using NGS to have valuable diagnostic image for genetic composition of embryo before implantation.
Procedure: NGS reading for Media Free DNA
DNA extracted from Blastomere used for aneuploidy screening.
Procedure: NGS reading for Media Free DNA
NGS reading for Media Free DNA instead of blstomer biopsy
DNA isolation
reading amplified DNA using NGS
Time frame: 2 years
NGS evaluation
Free DNA isolation and amplification using WGA
Time frame: 2 years
Comparison with cell reading using NGS
compare the obtained result with the results provided collected for the same embryo using its blastomer for PGS
Time frame: 2 years
No study locations are listed for this record.
Plan to share: Yes — To publish it when it is completed.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: once final results released.
Access criteria: 01-December 2019
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.
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Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Al Baraka Fertility Hospital