An interventional study of Polysomnography , blood collection, bone densitometry and Functional respiratory explorations in Obstructive Sleep Apnea, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to male participants aged 20 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-08-24.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Basic science
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
2,162 studies on the registry are indexed under Sleep Apnea Syndromes; 290 are open to participants now.
This study's enrollment of 53 is close to the median of 53 across 1,386 interventional studies indexed under Sleep Apnea Syndromes.
Browse Sleep Apnea Syndromes studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patient:
Healthy volunteers:
Exclusion Criteria
All subjects:
Patients with severe OSA (AHI \> 30)
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
Patients with moderate OSA (5 \< AHI ≤ 30)
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
Healthy volunteers (AHI ≤ 5)
Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "
Telomere length of circulating leukocytes
Time frame: 4 weeks
Carotid-femoral pulse wave velocity
Time frame: 4 weeks
Bone density
Time frame: 4 weeks
Correlation between biological parameters and neuropsychological assessment
Time frame: 4 weeks
Markers of oxidative stress: Malondialdehyde, heme oxygenase-1
Time frame: 4 weeks
Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1
Time frame: 4 weeks
Markers of growth hormone axis (GH, IGF-1, IGFBP)
Time frame: 4 weeks
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris