An observational study in Schizophrenia, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-08-26.
Sponsored by University Hospital, Lille · Observational
Background:
Patients with schizophrenia are abnormally disturbed by information onsets, which may result in a disadvantage in filtering relevant information. It seems that they accord the same importance to all objects in a scene without taking into account the relevance of objects (cognitive salience) or their emotional charge (salience emotional).
The paradigm of change blindness offers the interesting possibility of studying sensitivity to the sudden irruption of visual information with ecological stimuli in schizophrenia. An increased attentional capture by the irruption of visual information would suggest better performance in patients than in healthy controls. Moreover, patients are disturbed to processing of emotional information, in this way we would like to measure the impact of emotional salience on the visual exploration.
Main aim:
The main objective is to evaluate, if patients with schizophrenia quickly detect changes occurring on irrelevant objects in the understanding of the scene.
Secondary objectives:
To evaluate in patients with schizophrenia the impact of emotional salience using the same paradigm.
To separate an explicit response (motors responses) with an implicit response (eye tracking measures).
Methodology:
30 patients with schizophrenia and 30 healthy controls were asked to detect changes in 96 scenes with 0 or 1 change (neutral or emotional changes). We will measure the participants' speed and accuracy in explicitly reporting the changes via motor responses and their capacity to implicitly detect changes via eye movements.
This study will include one visit:
A visuo-spatial task allowing to record saccadic eye movements (approximately 10 min).
The change blindness session lasted approximately 20 min.
3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.
This study's enrollment of 42 is below the median of 178 across 491 observational studies indexed under Schizophrenia.
Browse Schizophrenia studies →University Hospital, Lille is the lead sponsor of 625 studies on the registry; 141 are open to participants now.
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30 patients with schizophrenia and 30 healthy controls
Exclusion Criteria:
30 patients with schizophrenia (diagnosis based on the standard DSM criteria)
30 healthy controls without any psychiatric or neurological diagnosis
response time
The explicit response of the participants will be measure behaviourally by response time before the detection of neutral stimuli.
Time frame: 42 months
sensitivity index
Performances will be measure by a sensitivity index (D prime) which considers the number of correct detections compared with the missed detections and false alarms; thus it evaluates the capacity to discriminate the signal against a background noise.
Time frame: 42 months
implicit response
The implicit response will be measure by the localization and duration of fixations
Time frame: 42 months
emotional response
The emotional response will be measure by the localization, duration of fixations and performances for the detection of emotional stimuli
Time frame: 42 months
Plan to share: No
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University Hospital, Lille