An interventional study of evaluate the variations of transpulmonary pressure during the use of APRV by clinicians. in Patient Mechanically Ventilated With APRV Mode, sponsored by Assistance Publique Hopitaux De Marseille. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-11-14.
Sponsored by Assistance Publique Hopitaux De Marseille · Not applicable, Interventional, and Other
Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.
The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians
Assistance Publique Hopitaux De Marseille is the lead sponsor of 686 studies on the registry; 148 are open to participants now.
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Exclusion Criteria:
Other: evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.
Transpulmonary pressure
Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.
Time frame: 24 hours
Maximal value of transpulmonary pressure
Value of tidal volume \> 8 ml/kg
Time frame: 24 hours
This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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Assistance Publique Hopitaux De Marseille