An interventional study of Amino Acid Intake in Healthy, sponsored by University of Toronto. Completed at 1 site in Canada. Open to male participants aged 10 Years to 15 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-03-29.
Sponsored by University of Toronto · Not applicable, Interventional, and Basic science
Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).
Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.
Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.
The purpose of this study is to measure the protein requirement in adolescent, males using the IAAO technique in the presence of a variable intensity exercise stimulus.
University of Toronto is the lead sponsor of 397 studies on the registry; 59 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria (All Subjects):
Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d
Dietary Supplement: Amino Acid Intake
Amino acid intakes will be varied at 0.2-2.67 g/kg/d
13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)
Each trial day will assess a different protein intake with 13CO2 excretion defining the level of protein adequacy. Each trial day will be separated by \~1wk washout with all trial being completed in approximately 3 months.
Time frame: 4 hours per study day
[13C]Phenylalanine Oxidation (µmol/kg/h)
Each trial day will assess a different protein intake with 13CO2 excretion defining the level phenylalanine oxidation being used as a secondary marker of protein adequacy. Each trial day will be separated by \~1wk washout with all trial being completed in approximately 3 months.
Time frame: 4 hours per study day
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Toronto