CompletedNCT02858765CHRONOSOMNOUpdated Dec 19, 2025

Influence of Light on Sleep, Awakening, Electroencephalogram (EEG) and Cognitive Performances

An interventional study of Application of white polychromatic light for 2h30 at different times of day in Human Sleep and Chronobiology, sponsored by University Hospital, Strasbourg, France. Completed at 1 site in France. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-19.

Sponsored by University Hospital, Strasbourg, France · Not applicable, Interventional, and Basic science

Phase: Not applicable
Study type: Interventional
Enrollment: 92
Allocation: Randomized
Ages: 18 Years to 40 Years
Sex: All

Study summary

The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances. The study aim also to evaluate techniques for registration and analysis of the EEG over periods of time.

Conditions studied

Human Sleep and Chronobiology

In context

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 966 studies on the registry; 342 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 40 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Inclusion criteria

Male or female
Aged 18 to 40 years
With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2
Healthy subject determined by a clinical examination, a psychological interview, a blood test, a urine analysis and an ophthalmologic examination
Topic Subject with a score \<6 questionnaire PSQI ("Sleep Questionnaire Pittsburgh")
Subject agreeing to maintain a regular sleep/wake rhythm during the study
Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs, cannabis or other drugs during the study
Signed informed consent
Subject affiliated to a social protection scheme

Exclusion criteria

Exclusion Criteria:

somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual
immune system diseases
kidneys and urinary tract diseases
endocrine and metabolic diseases
neurological diseases
infectious diseases
thrombocytopenia or other malfunction of blood platelets
Subject with risk of thrombosis, including subject with a history of phlebitis, smoker under oral contraceptive...
Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs, cannabis, or any other drug
Subject treatment contraindicated or inadvisable in combination with heparin
Allergy to neoprene or lycra
Dysfunction of the temporomandibular joint (TMJD)
Blood donation in the previous 3 months before the inclusion
Participation in other clinical trials in the previous 3 months before the inclusion
Work by shifts in the year preceding the inclusion
Trans-meridian travel (> 2 time zones) in the month previous the inclusion
Contraindications to the use of the medical device
Impossibility to give enlightened information (subject in an emergency situation, understanding difficulties,...)
Subject under safeguard of justice
Subject under tutorship or curatorship
Pregnancy (women of childbearing age)
Breastfeeding

Study design

Phase: Not applicable
Primary purpose: Basic science
Allocation: Randomized
Intervention model: Parallel assignment
Masking: None (open label)
Enrollment: 92 participants (actual)

Study arms

Experimental
white polychromatic light A
Other: Application of white polychromatic light for 2h30 at different times of day
Experimental
white polychromatic light B
Other: Application of white polychromatic light for 2h30 at different times of day
Experimental
white polychromatic light C
Other: Application of white polychromatic light for 2h30 at different times of day
Experimental
white polychromatic light D
Other: Application of white polychromatic light for 2h30 at different times of day

Interventions

OtherApplication of white polychromatic light for 2h30 at different times of day

What researchers measure

Primary outcomes

Analysis of EEG activity
sleep fragmentation
Time frame: up to 56 hours
Cognitive performances assessed using Psychomotor vigilance task (PVT)
Psychomotor vigilance task (PVT)
Time frame: up to 56 hours
Cognitive performances assessed using Sustained Attention to Response Task (SART)
Sustained Attention to Response Task (SART)
Time frame: up to 56 hours
Cognitive performances assessed using Digit Symbol Substitution Test (DSST)
Digit Symbol Substitution Test (DSST)
Time frame: up to 56 hours
Cognitive performances assessed using N-back tasks
N-back tasks
Time frame: up to 56 hours
Cognitive performances assessed using Paced Visual Serial Addition Task (PVSAT)
Paced Visual Serial Addition Task (PVSAT)
Time frame: up to 56 hours
Cognitive performances assessed using Visual analogue scales (VAS) for motivation
Visual analogue scales (VAS) for motivation
Time frame: up to 56 hours
Cognitive performances assessed using Positive and Negative Affect Scale (PANAS)
Positive and Negative Affect Scale (PANAS)
Time frame: up to 56 hours
Cognitive performances assessed using Karolinska Sleepiness Scale (KSS)
Karolinska Sleepiness Scale (KSS)
Time frame: up to 56 hours
Cognitive performances assessed using Visual Comfort Scale (VCS)
Visual Comfort Scale (VCS)
Time frame: up to 56 hours
Cognitive performances assessed using Racing and Crowded Thoughts Questionnaire (RCTQ)
Racing and Crowded Thoughts Questionnaire (RCTQ)
Time frame: up to 56 hours
Cognitive performances assessed using Mental Effort Rating Scale (RSME)
Mental Effort Rating Scale (RSME)
Time frame: up to 56 hours
Cognitive performances assessed using Karolinska Drowsiness Test (KDT)
Karolinska Drowsiness Test (KDT)
Time frame: up to 56 hours

Study locations

1 site

Hôpitaux Universitaires de Strasbourg
Strasbourg, 67091, France

References and documents

Publications

Glacet R, Reynaud E, Robin-Choteau L, Reix N, Hugueny L, Ruppert E, Geoffroy PA, Kilic-Huck U, Comtet H, Bourgin P. A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study. Chronobiol Int. 2023 Feb;40(2):123-131. doi: 10.1080/07420528.2022.2150554. Epub 2022 Dec 15. PubMed 36519316 ↗
Walter A, Martz E, Weiner L, Comtet H, Glacet R, Kilic-Huck U, Bourgin P, Schroder CM, Weibel S. Sleep, rest-activity rhythm, cognitive and emotional symptoms in adult ADHD: unraveling the links with an actimetry-based approach. BMC Psychiatry. 2026 Mar 9;26(1):317. doi: 10.1186/s12888-026-07947-9. PubMed 41803808 ↗

Individual participant data

Plan to share: No

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Dec 19, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02858765
Lead sponsor: University Hospital, Strasbourg, France
Responsible party: Sponsor
First posted: Aug 8, 2016
Start date: Jun 2016
Primary completion: Jun 2019
Completion: Jun 2019
Last update: Dec 19, 2025

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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