An interventional study of stimulation on painful area (area allodynic) and same stimulation on non-painful area in Neuropathic Pain, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Terminated at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-09-28.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Not applicable, Interventional, and Other
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity.
Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally.
The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.
1,287 studies on the registry are indexed under Neuralgia; 256 are open to participants now.
This study's enrollment of 41 is below the median of 52 across 973 interventional studies indexed under Neuralgia.
Browse Neuralgia studies →Centre Hospitalier Universitaire de Saint Etienne is the lead sponsor of 578 studies on the registry; 128 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: stimulation on painful area (area allodynic) · Other: same stimulation on non-painful area · Radiation: MRI scan
Other: stimulation on painful area (area allodynic) · Other: same stimulation on non-painful area · Radiation: MRI scan
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
2 sessions for 10 minutes : * 11 controls stimulations for 6 s each spaced 20 s without stimulation. * 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.
the deafferentation rate
the deafferentation rate measured with thermo-test
Time frame: at baseline
gray matter rate
gray matter rate measured with MRI scan
Time frame: at baseline
Analysis pain
Measured by visual analogue scale (0 to 10)
Time frame: at baseline
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Saint Etienne