An interventional study of MRI scan in Neuropathic Pain, sponsored by Centre Hospitalier Universitaire de Saint Etienne. Terminated at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-09-28.
Sponsored by Centre Hospitalier Universitaire de Saint Etienne · Not applicable, Interventional, and Other
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain.
It induces a loss of sensitivity and likely reorganization of brain activity that are causing pain and which are the subject of this study.
Previous studies in functional neuroimaging has focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The authors failed to assess the part of the effect of the loss of sensory afferents (deafferentation) and the basal brain function.
Indeed, the operation without any sensory stimulation is not known yet is the initial level of activity which is the benchmark for studying brain function during stimulation. The objective of this study is to understand what are the cortical systems of allodynic dysfunctional in patients compared with controls at baseline.
1,287 studies on the registry are indexed under Neuralgia; 256 are open to participants now.
This study's enrollment of 68 is above the median of 52 across 973 interventional studies indexed under Neuralgia.
Browse Neuralgia studies →Centre Hospitalier Universitaire de Saint Etienne is the lead sponsor of 578 studies on the registry; 128 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria for patients :
Inclusion Criteria for witnesses :
Exclusion Criteria for 2 groups :
MRI scan
Radiation: MRI scan
MRI scan
Radiation: MRI scan
MRI scan
Radiation: MRI scan
cerebral blood flow
quantified with MRI scan
Time frame: at baseline
rate of grey matter
difference between groups
Time frame: at baseline
structure of the networks
Determine if structure of the networks is different between patients and controls. Measured with MRI scan.
Time frame: at baseline
connection of the networks
Determine if connection of the networks is different between patients and controls. Measured with MRI scan.
Time frame: at baseline
cortical loss
Assess the cortical loss of the patient group compared to controls. Measured with MRI scan.
Time frame: at baseline
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre Hospitalier Universitaire de Saint Etienne