An interventional study of ingestion of a test meal with sweetener and ingestion of a test meal with sweetener in Normal Subjects, sponsored by University of Lausanne. Completed at 1 site in Switzerland. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-26.
Sponsored by University of Lausanne · Not applicable, Interventional, and Basic science
This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.
This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).
University of Lausanne is the lead sponsor of 54 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Effects of co-ingestion of artificially sweetened beverage on the response to a test meal
Other: ingestion of a test meal with sweetener
Effects of co-ingestion of sugar-sweetened beverage on the response to a test meal
Other: ingestion of a test meal with sweetener
Effects of co-ingestion of water on the response to a test meal
Other: ingestion of a test meal with water
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters
Spatio-temporal brain dynamics
Spatio-temporal brain dynamics to the viewing of food will be assessed by means of electroencephalography recordings.
Time frame: differences observed between 60 min before and 60 min after ingestion of a test meal
Changes in concentration of blood insulin
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Changes in concentration of blood triglyceride
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Changes in concentration of blood Fibroblast Growth Factor (FGF)-21
Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal
Time frame: -120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
spontaneous food intake
Food intake behavior will be assessed by monitoring spontaneous food intake when offered a free-choice buffet.
Time frame: 240 min after ingestion of a test meal
Plan to share: No
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This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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University of Lausanne