An observational study in Discriminate Obese Children at Risk for Diabetes., sponsored by Nanjing Medical University. Completed at 1 site in China. Open to participants aged 48 Months to 72 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-25.
Sponsored by Nanjing Medical University · Observational
Childhood obesity certainly increases susceptibility to type 2 diabetes (T2D) in adulthood. Recently, microRNAs (miRNAs) are closely related to various diseases and have been suggested as valuable biomarkers. Here, we sought to identify potential miRNAs to discriminate obese children at risk for diabetes in future.
This study was designed to screen the circulating miRNAs in association with progression from children obesity to type 2 diabetes (T2D) in adulthood. Serum samples were evaluated in a 3 step procedure: 1) discovery study, in which samples from obese children and healthy controls were pooled for miRNA sequecing experiment; 2) cross-sectional validation study, in which miRNAs of interest were validated in all individuals (obese children, overweight children and normal controls); 3) longitudinal validation study, in which the candidate miRNAs were estimated in newly diagnosed diabetes patients and normal glucose tolerance controls (NGT). The final determined miRNAs were further confirmed though primary function studies.
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This study's enrollment of 535 is above the median of 233 across 2,220 observational studies indexed under Diabetes Mellitus.
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Children recruiters were categorized into three groups: obesity, overweight and normal control based on World Health Organization child growth standards. Adults with type 2 diabetes were defined if the individual had a fasting plasma glucose (FPG) level ≥ 7.0 mmol/L.
Obese preschoolers; Adults with type 2 diabetes; Age-matched healthy controls.
Exclusion Criteria:
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Children recruiters were categorized into three groups: obesity, overweight and normal control based on World Health Organization child growth standards.
Adults with type 2 diabetes were defined if the individual had a fasting plasma glucose (FPG) level ≥ 7.0 mmol/L.
It is expected that the identification of circulating miRNAs as potential biomarkers may facilitate to the diagnosis of obese preschoolers at high risk for developing diabetes.
Time frame: 50-70 month old
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Nanjing Medical University