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CompletedNCT02842944BEACONUpdated Jun 25, 2026

Weaning From Mechanical Ventilation Comparison of Open-loop Decision Support System and Routine Care

An interventional study of open loop weaning group (Beacon) and Routine care in Respiration, Artificial, sponsored by Centre Hospitalier Universitaire, Amiens. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-25.

Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
29
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to compare mechanical ventilation following advice from the Beacon Caresystem to that of routine care in patients from the state of requiring invasive mechanical ventilation until successful extubation. The Beacon Caresystem will be compared to routine care to investigate whether use of the system results in similar care and reduced time for weaning from mechanical ventilation.

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Conditions studied

  • Respiration, Artificial
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In context

Respiratory Aspiration

1,092 studies on the registry are indexed under Respiratory Aspiration; 216 are open to participants now.

This study's enrollment of 29 is below the median of 42 across 881 interventional studies indexed under Respiratory Aspiration.

Browse Respiratory Aspiration studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 576 studies on the registry; 178 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patient is on invasive mechanical ventilation more 48 hours
  • Age > 18 years
  • Patients are ventilated using Maquet Servo-I, Draeger Infinity V500 or Draeger Evita XL mechanical ventilators in "pressure support", "volume controlled", or "pressure controlled" ventilation modes.
  • Haemodynamically stable (mean blood pressure ≥ 65 mmHg)
  • Patients or, in the case that the patient is unable, next of kin understand and accept oral and written information describing the study or patient consent retrospectively in case of emergency inclusion.

Exclusion criteria

Exclusion Criteria:

  • The absence of an arterial catheter for blood sampling.
  • Medical history of home mechanical ventilation
  • Severe ARDS (PaO2/FiO2 ≤ 100 mmHg)
  • Head trauma or other conditions where intra-cranial pressure may be elevated and tight regulation of arterial CO2 level is paramount.
  • Severe neurological patients (Glasgow coma score \<10, neurologic damage with limited prognosis, stroke hemiplegia).
  • Known or suspected severe myopathy or neuropathy (including ICU neuromyopathy)
  • Quadriplegia
  • Severe heart failure
  • Broncho alveolar fistula with more than 100ml leakage
  • History of home mechanical ventilation
  • Pregnancy.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Investigator)
Enrollment
29 participants (actual)

Study arms

  • Experimental
    open loop weaning group (Beacon)

    mechanical ventilation following advice from the Beacon Caresystem

    Device: open loop weaning group (Beacon)

  • Active comparator
    Routine care

    * Connect and start Beacon with advice disabled * Standardized routine care

    Other: Routine care

Interventions

  • Deviceopen loop weaning group (Beacon)

    mechanical ventilation following advice from the Beacon Caresystem

  • OtherRoutine care

    Standardized routine care

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What researchers measure

Primary outcomes

  1. Duration of mechanical ventilation

    time from initial intubation and until successful extubation, with successful extubation defined as ≥ 7 days of unassisted spontaneous breathing after extubation.

    Time frame: 14 days

  2. Time to successful extubation

    time from randomization and until successful extubation.

    Time frame: Successful extubation is defined as ≥ 7 days of unassisted spontaneous breathing after extubation

  3. Time from support mode to successful extubation

    the time after point of randomization, from initiation of support modes of ventilation and until successful extubation

    Time frame: 14 days

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Study locations

1 site
  • CHU Amiens
    Amiens, 80054, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02842944
Lead sponsor
Centre Hospitalier Universitaire, Amiens
Responsible party
Sponsor
First posted
Jul 25, 2016
Start date
Dec 12, 2017
Primary completion
Apr 15, 2025
Completion
Apr 15, 2025
Last update
Jun 25, 2026

Study contacts

Elie ZOGHEIB, PhD
principal investigator · CHU Amiens

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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