An observational study in Oropharyngeal Gram-negative Bacilli Colonization, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-06-12.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
In this prospective observational study we aim to determine the prevalence of oropharyngeal and rectal Gram-negative bacilli colonization in healthy subjects, and their susceptibility to chlorehexidine. We plan to recruit 100 healthy volunteers secondary endpoints are to determine the phylogentic characteristics of E. coli isolates; to compare the phylogentic characteristics of oropharyngeal and rectal of predominant GNB colonization.
In this prospective observational study we aim to determine the prevalence of oropharyngeal and rectal Gram-negative bacilli colonization in 100 healthy subjects, and their susceptibility to chlorehexidine. Each participant will undego a oropharyngeal swab collection and a rectal swab at day 0. The Gram-negative bacilli colonization will be identified, E. coli isolates will be studied in terms of phylogeny; gram-negative isolates will be studied in terms of antimicrobial and chlorhexidine susceptibility. The primary objective is to determine the prevalence of oropharyngeal Gram-negative bacilli colonization. The secondary objectives are to determine the chlorhexidine and antimicrobial susceptibility of such colonization; to determine the phylogentic characteristics of oropharyngeal and rectal predominant E. coli isolates; to compare the phylogentic characteristics of oropharyngeal and rectal E. coli isolates.
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healthy volonteers
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Exclusion Criteria:
oropharyngeal and rectal swabbing to collect Gram-negative bacilli
Other: oropharyngeal swabbing · Other: rectal swabbing
microbiological sampling will be performed on buccal mucosa with standard swab. only one sample will be done
same process as oropharyngeal swabbing will be used to collect rectal microbiological sample
proportion of patients with an oropharyngeal gram-negative colonization
Time frame: Day 1
incidence of the a GNB oropharyngeal colonization
Time frame: Day 1
comparision of the predominant fecal flora with GNB oropharyngeal colonization
Time frame: Day 1
characterization of antimicrobial and chlorhexidine susceptibility of Gram negative bacteria from oropharyngeal colonization
Time frame: Day 1
phylogenetic and virulence factor content of E. coli oropharyngeal and rectal colonization
Time frame: Day 1
Plan to share: Undecided
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This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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