An observational study in Chronic Kidney Disease and End-stage Kidney Disease, sponsored by University of Minnesota. Withdrawn at 1 site in United States. Open to participants aged 45 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-25.
Sponsored by University of Minnesota · Observational
This study has two major purposes:
These purposes will be achieved by performing pilot studies with cohorts of patients.
This study is observational with no intervention applied for the patients. In this study, multiple anatomic and functional MRI methods will be performed with three cohorts of patients. In addition to anatomic MRI methods, non-contrast enhanced functional MRI methods will also be applied to evaluate tissue perfusion and vascular reactivity in these patients.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
Browse Kidney Diseases studies →University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.
Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
The study population will include three main cohorts of patients: 20 ESRD patients with their transition to dialysis treatment, 20 CKD controls and 20 non-CKD controls. Based on the investigators previous experience, about 20% of recruited subjects may not be able to finish the proposed studies. Therefore, a conservative estimate of the total number of subjects to be recruited is 72.
Exclusion Criteria:
Patients without CKD (eGFR ≥ 60 ml/min/1.73 mm2) (non-CKD controls). No intervention but only observational.
Other: No intervention but only observational
Patients with Patients with moderate to severe CKD (eGFR ranging from 26 to 44 ml/min/1.73 mm2). No intervention but only observational.
Other: No intervention but only observational
Patients with advanced CKD (eGFR \< 15 ml/min/1.73 mm2), preparing for or undergoing the standard thrice-weekly HD or standard PD treatment (end-stage renal disease (ESRD) patients). No intervention but only observational.
Other: No intervention but only observational
This study is a cross-sectional and observational MRI study with three cohorts of patients, and no interventions will be applied.
MRI measured perfusion for each patient group
MRI measurements will be summarized for each patient group by using mean and standard deviation or standard error.
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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University of Minnesota