CClinicalTrials.gg
CompletedNCT02830217Updated Oct 2, 2019

Evaluation of Soluble ST2 in Patients Receiving Primary PCI With ST-elevation Myocardial Infarction

An observational study in Myocardial Infarction and Shock, sponsored by Wuhan Asia Heart Hospital. Completed at 1 site in China. Open to participants aged 25 Years to 80 Years. Per ClinicalTrials.gov, last updated 2019-10-02.

Sponsored by Wuhan Asia Heart Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
25 Years to 80 Years
Sex
All
01

Study summary

ST-elevation myocardial infarction (STEMI) is an urgent symptom associated with sudden myocardial ischemia and ST segment elevated in ECG. Primary percutaneous coronary intervention (PCI) re-open infarct artery efficiently for STEMI patients. However, patients are readmitted shortly after the primary PCI for several unfavorable clinical outcomes including thrombosis in stent, recurrence of myocardial infarction, stroke, and heart failure. This study is intended to test the predictive ability of a new biomarker soluble ST2 (sST2) in peripheral blood. Previous studies have shown that elevated sST2 is highly associated with unfavorable clinical outcomes of patients with ischemia heart diseases and heart failure. This study will further investigate the ability of sST2 to predict unfavorable outcomes for STEMI patients after primary PCI.

02

Conditions studied

  • Myocardial Infarction
  • Shock

Keywords

  • STEMI
  • primary PCI
  • sST2
  • prognosis
03

In context

Myocardial Infarction

2,744 studies on the registry are indexed under Myocardial Infarction; 418 are open to participants now.

This study's enrollment of 200 is below the median of 500 across 983 observational studies indexed under Myocardial Infarction.

Browse Myocardial Infarction studies →

Lead sponsor

Wuhan Asia Heart Hospital is the lead sponsor of 19 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Chinese han population in middle China

Inclusion criteria

  • Patients with first onset STEMI receive primary PCI according to 2013 ACCF/AHA guideline for management of STEMI

Exclusion criteria

Exclusion Criteria:

  • Patients with previous stroke, pneumonia, cirrhosis, autoimmune diseases or severe infection are excluded from this study.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • STEMI patients having primary PCI

    Patients with STEMI receiving primary PCI in Wuhan Aisa Heart Hospital are included in this study. All patients are the first time to have STEMI, and primary PCIs are performed according to 2013 ACCF/AHA guideline for the management of STEMI. Patients with previous stroke, pneumonia, cirrhosis, autoimmune diseases are excluded from this study.

06

What researchers measure

Primary outcomes

  1. stent restenosis

    Evidence of stent restenosis of the patients receiving primary PCI, confirmed by coronary angiography when patients are readmitted due to the related symptoms.

    Time frame: one year after primary PCI

  2. recurrence of myocardial infarction

    Evidence of myocardial infarction of the patients receiving primary PCI, confirmed by coronary angiography or ECG when patients are readmitted due to the related symptoms.

    Time frame: one year after primary PCI

  3. heart failure

    Evidence of heart failure of the patients receiving primary PCI, confirmed by clinical diagnosis when patients are readmitted due to the related symptoms.

    Time frame: one year after primary PCI

  4. cardiac death

    Evidence of death due to the cardiac dysfunction of the patients receiving primary PCI.

    Time frame: one year after primary PCI

07

Study locations

1 site
  • Wuhan Asia Heart Hospital
    Wuhan, Hubei 430022, China
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 2, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02830217
Lead sponsor
Wuhan Asia Heart Hospital
Responsible party
Xuan Zheng (vice director of laboratory of molecular cardiology, Wuhan Asia Heart Hospital) — Principal investigator
First posted
Jul 12, 2016
Start date
Dec 2015
Primary completion
Nov 30, 2018
Completion
Dec 20, 2018
Last update
Oct 2, 2019

Study contacts

Xuan Zheng, MD,PhD
principal investigator · Wuhan Asia Heart Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion