An observational study in Autoimmune Hemolytic Anemia, sponsored by Centre Hospitalier Universitaire Dijon. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-15.
Sponsored by Centre Hospitalier Universitaire Dijon · Observational
T follicular helper (TFH) cells represent a T cell subset dedicated to the activation of B cells. They have been involved in the pathogenesis of autoimmune diseases in humans such as lupus and Sjögren disease. We recently showed that TFH are implicated in the activation of autoreactive B lymphocytes during ITP. Autoimmune hemolytic anemia (AIHA) is an autoimmune disease due to antibodies targeting red blood cells. To date, the role of TFH in the pathogenesis of AIHA is not known.
We hypothesize that AIHA is associated with an increase in the number and/or function of TFH, that could participate in the activation of autoreactive B lymphocytes.
1,733 studies on the registry are indexed under Anemia; 246 are open to participants now.
This study's enrollment of 25 is below the median of 200 across 326 observational studies indexed under Anemia.
Browse Anemia studies →Centre Hospitalier Universitaire Dijon is the lead sponsor of 495 studies on the registry; 105 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with a diagnosis of warm AIHA Patients with non-auto-immune hemolytic anemia
Patients with a diagnosis of warm AIHA defined by
Patients
Control population
Exclusion Criteria:
Biological: blood sample · Procedure: spleen sample
Biological: blood sample · Procedure: spleen sample
the proportion of circulating T follicular helper lymphocytes (TFH) in patients with Autoimmune Hemolytic Anemia (AIHA) and in control subjects.
Time frame: baseline
the proportion of circulating TFH in patients with Autoimmune Hemolytic Anemia (AIHA), at diagnosis and after 3 months of treatment with steroids
Time frame: through study completion, an average of 1 year
This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire Dijon