An interventional study of active rTMS and sham rTMS in Smoking Cessation and Addiction, sponsored by Centre Hospitalier Universitaire Dijon. Completed at 1 site in France. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-02-06.
Sponsored by Centre Hospitalier Universitaire Dijon · Not applicable, Interventional, and Treatment
The fight against smoking is a public health priority. Without help, fewer than 5% of des smokers are abstinent at 12 months after smoking cessation.
Despite well-managed attempts at smoking cessation with nicotine substitutes, the rate of success at 12 months in patients dependent on nicotine is only 18%. Moreover, other therapeutic strategies (acupuncture, hypnosis…) have not proved to be effective.
The investigators propose a new therapeutic strategy for smoking cessation, which is based on associating nicotine substitutes (to reduce physical symptoms of weaning from nicotine) with rTMS at 1 Hz to the right DorsoLateral PreFrontal Cortex (DLPFC) for 2 weeks (to diminish craving for tobacco). The principal objective is to improve the success rate for smoking cessation attempts in patients who are highly dependent on nicotine, and who have failed using usual smoking cessation strategies.
304 studies on the registry are indexed under Smoking Cessation; 139 are open to participants now.
This study's enrollment of 39 is below the median of 154 across 285 interventional studies indexed under Smoking Cessation.
Browse Smoking Cessation studies →Centre Hospitalier Universitaire Dijon is the lead sponsor of 495 studies on the registry; 105 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Device: active rTMS
Device: sham rTMS
Change from Baseline score of Tabacco Craving Questionnaire (TCQ)
Time frame: at Week 0, Week 1, Week 2, Week 6 and Week 12 after stimulation
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire Dijon