Evaluation of the Alveolar Recruitment Obtained During Non-invasive Ventilation After Cardiac Surgery (NCT02804997)

Study summary

The great majority of cardiac surgery patients develop a degree of post-operatory respiratory failure. This is due to several factors. The predominant element in the onset of this respiratory impairment is the constitution of foci of pulmonary atelectasis, caused by peroperative hypoventilation (in the presence or absence of ECC). The incidence has been evaluated at between 54% and 92%, depending on the study. The use of NIV (non-invasive ventilation) might (through the application of continuous positive expiratory pressure) help to counter the development of these atelectasic foci.

Conditions studied

Thoracic Surgery

Keywords

non-invasive ventilation
cardiac surgery

In context

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 576 studies on the registry; 178 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

patients in the post-operative phase after elective cardiac surgery for aortic or mitral valve replacement, coronary revascularization or mixed surgery, hypoxemia or hypercapnia, with an indication for NIV, hemodynamic stability, prior consent, spontaneous ventilation, social security coverage

Inclusion criteria

Age ≥18
in the post-operative phase after elective cardiac surgery for aortic or mitral valve replacement, coronary revascularization or mixed surgery, hypoxemia or hypercapnia, with an indication for NIV,
hemodynamic stability
prior consent
spontaneous ventilation
social security coverage.

Exclusion criteria

Exclusion Criteria:

Under-18 patients
complex cardiac surgery
pregnancy
pre-existing chronic obstructive respiratory disease (COPD > stage II)
legal guardianship
incarceration

Study design

Observational model: Case-crossover
Time perspective: Prospective
Enrollment: 17 participants (actual)
Patient registry: No

What researchers measure

Primary outcomes

Quantitative evaluation by thoracic CT scan
Quantitative evaluation performed by thoracic CT scan of alveolar recruitment induced by NIV after cardiac surgery
Time frame: 3 hours

Study locations

1 site

CHU Amiens
Amiens, 80054, France

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Oct 1, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT02804997
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Responsible party: Sponsor
First posted: Jun 17, 2016
Start date: May 13, 2015
Primary completion: Jan 27, 2017
Completion: Jan 27, 2017
Last update: Oct 1, 2018

Study contacts

Elie ZOGHEIB, PhD

principal investigator · CHU Amiens

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Evaluation of the Alveolar Recruitment Obtained During Non-invasive Ventilation After Cardiac Surgery