An observational study in Heart Failure, sponsored by Tbilisi State University. Completed. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2017-10-11.
Sponsored by Tbilisi State University · Observational
The aim of the study is to explore association between increased central venous pressure, Ejection Fraction and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2. The pilot study was set to provide the expected correlation coefficient for a sample size determination of the subsequent study.
OBJECTIVES
The aim of the study is to explore association between increased central venous pressure (CVP), Ejection Fraction (EF) and renal dysfunction (eGFR) in patients with Cardio-Renal Syndromes type 1 and 2.
BACKGROUND
The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. Recent investigations suggest that management of patients based on low-flow theory does not lead to improved outcomes. Relative importance of right heart dysfunction (manifested as increased CVP) has not been evaluated . Precise understanding of bidirectional pathways by which the heart and kidneys influence each other is necessary to define optimal treatment strategies specific to the subtypes, as therapies directed towards one organ system may have beneficial or unfavorable effects on the other.
METHODS
The study is of non-experimental (observational) type, based on retrospective chart review. The patients' personal identifiers are concealed and an anonymized datasets used (unique code given to each patient, which is kept secure under the control of hospital staff).
76 studies on the registry are indexed under Cardio-Renal Syndrome; 22 are open to participants now.
This study's enrollment of 11 is below the median of 150 across 26 observational studies indexed under Cardio-Renal Syndrome.
Browse Cardio-Renal Syndrome studies →This is the only study on the registry with Tbilisi State University as lead sponsor.
Counted across the registry records on this site, refreshed daily.
patients who underwent in-patient treatment at medical centers
Exclusion Criteria:
CVP measurements had been performed with an electronic pressure transducer in spontaneously breathing non-ventilated patients. Central vein access was established trough the subclavian or internal jugular veins. Mean CVP was recorded for each patient, measured in mmHg.
renal impairment (defined as a Glomerular Filtration Rate less than 60 mL/min per 1.73 m2)
Estimated Glomerular Filtration Rate has been assessed with the Modification of Diet in Renal Disease formula
Time frame: through study completion, an average of 1 year
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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