An observational study in Osteochondritis Dissecans, sponsored by University of Pennsylvania. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2026-05-27.
Sponsored by University of Pennsylvania · Observational
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Patients will be recruited and consented at the visit in which their eligibility is determined. Once a patient is eligible and provides informed consent, he or she will be in the study for up to 50 years, or until his or her OCD lesion is healed successfully.
At the initial visit, a subject will complete a basic medical history form, and three questionnaires: the IKDC Subjective questionnaire (ages over 18) or the PEDI-IKDC Subjective questionnaire (ages under 18); the KOOS questionnaire; and the Marx Activity Scale (adult) or Pedi-FABS Scale (pediatric). Patients will then continue with their normal course of care as determined by their surgeon and care team.
Mandatory surveys (same as above) will be collected from patients at 2 years, 5 years, 10 years, and 25 years. Patients who cannot return to clinic will have the option to complete the assessments and return in pre-stamped and addressed return envelopes provided by the clinical site the subject is a patient at. Any other follow-up visits between these time intervals will also be options for patients to complete these assessments, however patients will not complete them any closer than intervals 12 weeks apart in order to prevent redundancy.
Additionally, at the initial visit, the surgeon will complete a routine patient history and physical exam, which will be collected. Any surgical procedures or physical therapy a patient undergoes for treatment of his or her OCD lesion will also be documented and collected. At follow-up visits, surgeons will complete their own physical exam follow-up assessment forms, which will be collected.
30 studies on the registry are indexed under Osteochondritis Dissecans; 7 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 130 across 12 observational studies indexed under Osteochondritis Dissecans.
Browse Osteochondritis Dissecans studies →University of Pennsylvania is the lead sponsor of 1,668 studies on the registry; 235 are open to participants now.
Of its 158 completed or terminated interventional studies of FDA-regulated products, 109 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years.
Other: Other: observational only- no intervention
Other: observational only- no intervention
IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Time frame: baseline up to 50 years
PEDI-IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Time frame: baseline up to 50 years
KOOS Knee score
The Knee injury and Osteoarthritis Outcome Score (KOOS) evaluates short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis.
Time frame: baseline up to 50 years
Marx Activity Score questionnaire
Measure of physical activity at healthiest and most active state from time of taking to year prior.
Time frame: baseline up to 50 years
Pedi-FABS Score
An eight-item scale that measures level of physical activity and fitness.
Time frame: baseline up to 50 years
Radiographic Healing
Visualization of bone healing through x-ray images.
Time frame: baseline up to 50 years
Plan to share: Undecided
Started May 2014 (actual). Primary completion is estimated for May 2074, 720 months after the start.
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