An observational study in Cognition Disorders, sponsored by Mid and South Essex NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-12-22.
Sponsored by Mid and South Essex NHS Foundation Trust · Observational
The study objective is to correlate global cognition and episodic memory performance to resting state fMRI functional connectivity. This is a non-treatment, prospective, natural history data collection study in a cross-sectional cohort of patients with cognitive impairment.
At present, Magnetic Resonance Imaging (MRI) is widely used along with other tests to help diagnose dementia, however diagnosis still remains challenging. There is currently a focus on the usefulness of resting state functionalMRI (RS fMRI) as a way of establishing differences in functional connectivity between healthy subjects and those with various neurodegenerative disorders. Although the potential for RS fMRI to be used as a biomarker for neurological diseases looks promising, further research is needed, especially regarding validation of normal values and seed-based functional connectivity. Further research into this area will help to improve the ability to appropriately classify new subjects and ultimately allow use of RS functional connectivity as a biomarker. This is a nontreatment, prospective, natural history data collection that aims to analyse functional connectivity in a cohort of patients with suspected cognitive impairment. Correlation of global cognition and episodic memory performance to resting state fMRI functional connectivity will be evaluated. Patient population will include patients over the age of 18 with cognitive impairment and age and gender matched controls. Eligible patients will have to complete neuropsychological and clinical assessments and complete an fMRI scan prior to enrolment.Study duration is estimated at 4 years.
411 studies on the registry are indexed under Cognition Disorders; 90 are open to participants now.
This study's enrollment of 37 is below the median of 173 across 107 observational studies indexed under Cognition Disorders.
Browse Cognition Disorders studies →Mid and South Essex NHS Foundation Trust is the lead sponsor of 34 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with suspected cognitive impairment, mild cognitive impairment, autosomal dominant Alzheimer's disease, late onset Alzheimer's disease, Vascular dementia, Parkinson's dementia and age and gender matched controls.
Exclusion Criteria:
Medical History, Neuropsychological tests, clinical assessments, fMRI
Other: fMRI · Other: Neuropsychological tests
Medical History, Neuropsychological tests, clinical assessments, fMRI
Other: fMRI · Other: Neuropsychological tests
Functional MRI scan to be performed
Cognitive assessments will be performed, including Mini Mental State Examination, Rey Auditory Verbal Learning Test, Stroop, Visual Short Term Memory Assessment.
Evaluation of the functional connectivity in the Default Mode Network .
Evaluating the correlation of the Default Mode Network functional connectivity to types of dementia.
Time frame: 4 years
Correlation of cognitive performance to functional connectivity.
To evaluate the correlation between individual measures of functional connectivity and global and episodic cognitive performance as measured by neuropsychological tests.
Time frame: 4 years
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.
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Mid and South Essex NHS Foundation Trust