An observational study in Cushings Syndrome, sponsored by Haukeland University Hospital. Status unknown at 1 site in Norway. Open to participants aged 4 Years to 16 Years. Per ClinicalTrials.gov, last updated 2017-08-16.
Sponsored by Haukeland University Hospital · Observational
Cortisol overproduction ( Cushings syndrome) is a condition where the patient have a special fat distribution, with accumulation of fat around the abdomen and in the neck, with thinner limbs and weak musculature. The condition can be difficult to separate from adipositas in general. Screening for hypercortisolism in adults has been easier the last years, because we can measure free cortisol in saliva samples at late night. In children we still dont have reference ranges for saliva cortisol in children, so the screening is still troublesome, based on Collection of 24-hour urine.The meaning of this study is to establish reference ranges for saliva cortisol, and evaluate in a cohort with adipose children if screening with saliva cortisol is sensitive and specific enough to be the New screening test for hypercortisolism in children too.
the investigators have collected saliva samples morning and late evening for cortisol measurements in a total of 330 children ( 660 samples) in the age from 4 to 16 years ols. This samples are going to be used to define a reference range for saliva cortisol in children.
The investigators are then collecting 24 hour urine and saliva samples ( morning and late evening) from children at the obesity clinic Haukeland University hospital for verification of the reference range , and to estimate if the test is good enough to identify the patients that have Cushings syndrome.
Since the diagnose is very seldom in children, we will get help from a 3. line referral center in London to include patients with true Cushings syndrome.
123 studies on the registry are indexed under Cushing Syndrome; 37 are open to participants now.
This study's planned enrollment of 70 is below the median of 115 across 62 observational studies indexed under Cushing Syndrome.
Browse Cushing Syndrome studies →Haukeland University Hospital is the lead sponsor of 276 studies on the registry; 61 are open to participants now.
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The reference are made from healthy children included from kindergarden and Schools in the Bergen area. The age range from 4 to 16 years ols. The patient population is children refered to the obestity clinic at Haukeland University Hospital.
Inclusion Criteria:Children aged 4-16 years. Healthy population from selected kindergarten and Schools, and patients refered to the obesity clinic Haukeland University Hospital, for examination and optionally treatment.
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Exclusion Criteria:Use of any kind of steroids ( oral, liniments, inhalations etc)
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All children refered to the obesity clinic for examination and optionally treatment are invited.
Other: Children refered to the obesity clinic
Compere if urine cortisol is as good as saliva cortisol as a screening for hypercortisolism in children.
Number of patients with positive saliva cortisol measurement, not having Cushings syndrome.
Number of patients
Time frame: 2 years
Number of patients With negative saliva cortisol measurement , having Cushings syndrome.
Number of patients
Time frame: 2 years
This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Haukeland University Hospital