Plasma Exchange vs Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis

Browse trials for

• Pancreatitis 752

Keywords

• plasma exchange
• hypertriglyceridemia

Pancreatitis

752 studies on the registry are indexed under Pancreatitis; 181 are open to participants now.

This study's enrollment of 22 is below the median of 80 across 448 interventional studies indexed under Pancreatitis.

Lead sponsor

University Medical Centre Ljubljana is the lead sponsor of 284 studies on the registry; 71 are open to participants now.

Study arms

• Experimental
  plasma exchange

  plasma exchange, with 1.5 estimated plasma volume exchanged with albumin solution, using citrate anticoagulation, performed daily until triglycerides \<=10 mmol/l

  Procedure: plasma exchange

• Active comparator
  conservative treatment

  infusion of 5% glucose and insulin, to maintain blood glucose at 5-8 mmol/l

  Drug: conservative treatment

Interventions

• Procedureplasma exchange

  see arm description

• Drugconservative treatment

  see arm description

  Also known as: glucose and insulin

Primary outcomes

1. decrease in triglycerides

   as % of starting value

   Time frame: within first 24 h after admission

Secondary outcomes

1. time until triglycerides drop to <10 mmol/l

   expressed in days

   Time frame: by the end of hospital stay, up to 100 days

2. highest C-reactive protein (CRP)

   Time frame: by the end of hospital stay, up to 100 days

3. % of patients with severe pancreatitis

   Time frame: by the end of hospital stay, up to 100 days

Publications

• Gubensek J, Andonova M, Jerman A, Persic V, Vajdic-Trampuz B, Zupunski-Cede A, Sever N, Plut S. Comparable Triglyceride Reduction With Plasma Exchange and Insulin in Acute Pancreatitis - A Randomized Trial. Front Med (Lausanne). 2022 Apr 12;9:870067. doi: 10.3389/fmed.2022.870067. eCollection 2022. PubMed 35492338 ↗