An interventional study of Exercise in Obesity, sponsored by University of Toronto. Completed at 1 site in Canada. Open to male participants aged 10 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-02.
Sponsored by University of Toronto · Not applicable, Interventional, and Treatment
This study describes the effect of acute high intensity exercise at 70% VO2peak on inflammation, stress, appetite hormones and appetite in lean and obese children and adolescents.
In summary, exercise does induce a variety of metabolic mechanisms on a central and peripheral level, related to appetite other than solely gut peptides. The literature points towards a rather loose coupling when it comes to high intensity exercise and the suppression of food intake, without a clear explanation of the cause of exercise induced anorexia. This study is aimed to investigate high-intensity exercise and its effects on appetite and satiety hormones, inflammation, stress and eating behaviors on appetite and food intake.
The objective of the current study is to investigate the factors contributing to exercise-induced anorexia in lean and obese children, and maximize its translation into post-exercise suppression of food intake and promotion of negative energy balance particularly in obese children. It is hypothesized that high-intensity exercise would promote a greater suppression of food intake through suppression of appetite ratings via physiological mechanisms depending on stress and inflammation rather than gut peptides.
6,570 studies on the registry are indexed under Obesity; 1,718 are open to participants now.
This study's enrollment of 22 is below the median of 77 across 5,084 interventional studies indexed under Obesity.
Browse Obesity studies →University of Toronto is the lead sponsor of 403 studies on the registry; 57 are open to participants now.
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Exclusion Criteria:
Exercise at 70%VO2max on a recumbent bicycle for 30 minutes.
Other: Exercise
Resting
Exercise at 70%VO2max on a recumbent bicycle for 30 minutes to investigate the effects of exercise at high intensities on appetite and biomarkers of appetite and inflammation.
Appetite as assessed via visual analog scales
Appetite will be assessed via visual analog scales. Each item will be scored from 0-100; 0 not hungry; 100 very hungry
Time frame: Timeperiod of 2 hours during each study intervention.
Biomarkers of appetite
Biomarkers of appetite will be assessed such as A. Ghrelin; GLP-1; PYY and Leptin
Time frame: 4 timpoints during 2 hours during each study intervention.
Biomarkers of Inflammation
Biomarkers of inflammation will be assessed such as IL-6; IL-1beta; TNF-alpha; CRP
Time frame: 4 timpoints during 2 hours during each study intervention.
Biomarkers of Stress
Biomarkers of stress will be assessed such as Cortisol and Adrenalin
Time frame: 4 timpoints during 2 hours during each study intervention.
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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