A Phase 2/3 interventional study of Epidural anesthesia and intravenous analgesia in Acute Pancreatitis, sponsored by Hospital General Naval de Alta Especialidad - Escuela Medico Naval. Status unknown at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-01-11.
Sponsored by Hospital General Naval de Alta Especialidad - Escuela Medico Naval · Phase 2/3, Interventional, and Treatment
Acute pancreatitis is a common urgency with a mortality rate of up to 30% , decreased blood flow in the pancreatic microcirculation. It seems to be the main cause of the pathophysiology of acute pancreatitis. Today, there have been many attempts in the management of pancreatitis but no established management seems to be ideal. The epidural block is an anesthetic technique used to provide highly peri and post-operative analgesia, also plays an important role in improving the gastrointestinal vascular perfusion (due to sympathetic blockade that this technique produces) so this anesthetic technique is proposed as an alternative to both clinical treatment as an analgesic for acute pancreatitis.
The main objective of the study is to evaluate the therapeutic effects of epidural block in patients with acute pancreatitis, comparing day hospital stay among patients receiving intravenous analgesic treatment and patients who are undergoing epidural block.
It is a (prospective, comparative, longitudinal, experimental, randomized) controlled clinical trial. They include patients who are diagnosed with acute pancreatitis at the Naval General Hospital of High Specialty. Two groups were taken by random assignment.
752 studies on the registry are indexed under Pancreatitis; 181 are open to participants now.
This study's planned enrollment of 60 is below the median of 80 across 448 interventional studies indexed under Pancreatitis.
Browse Pancreatitis studies →Hospital General Naval de Alta Especialidad - Escuela Medico Naval is the lead sponsor of 9 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Epidural anesthesia placed at L1-L2 Epidural infusion of ropivacaine 0.2% + 3-4 mcg/ml fentanyl + saline 0.9% (100 ML) 3-5ml/ hr during 120 hours
Drug: Epidural anesthesia
ketorolac 1mg/kg every 8 hours or metamizol 15 mg/kg every 8 hrs and intravenous opioids (buprenorphine 3 mcg / kg or tramadol 1mg/ kg in continuos infusion
Drug: intravenous analgesia
Epidural anesthesia placed at L1-L2 Epidural infusion of ropivacaine 0.2% + 3-4 mcg/ml fentanyl + saline 0.9% (100 ML) 3-5ml/ hr during 120 hours
Also known as: ropivacaine + fentanyl epidural
ketorolac 1mg/kg every 8 hours or metamizol 15 mg/kg every 8 hrs and intravenous opioids (buprenorphine 3 mcg / kg or tramadol 1mg/ kg in continuos infusion
Also known as: nonsteroidal analgesics + opioids intravenous
Hospital days stay between two groups
Day hospital stay were compared between the analgesic management with epidural and intravenous analgesic management
Time frame: 10-15 days
Efficacy of Epidural pain control
Measured by pain scales the effectiveness of epidural use as an analgesic in acute pancreatitis
Time frame: 24, 48, 72, 96,120 hours
Decreased pancreatic enzymes
Recording every 24 hours of laboratory values, these values decreased observing and evaluating the clinical status of the patient
Time frame: 24,48,72,96,120 hours post dose
Complications associated by the epidural catheter
Complications by epidural catheter placement
Time frame: 24,48,72,96, 120 hours post epidural block
This study is status unknown, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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Hospital General Naval de Alta Especialidad - Escuela Medico Naval