An interventional study of Remote Ischemic Preconditioning Training Apparatus in Duchenne Muscular Dystrophy (DMD), sponsored by General Hospital of Chinese Armed Police Forces. Status unknown at 1 site in China. Open to male participants aged 2 Years to 6 Years. Per ClinicalTrials.gov, last updated 2015-11-25.
Sponsored by General Hospital of Chinese Armed Police Forces · Not applicable, Interventional, and Treatment
Background: Duchenne muscular dystrophy (DMD) is an X chromosome recessive hereditary disease and mainly characterized by progressive muscle weakness and atrophy. Glucocorticoid is the only proven effective medicine,while side effects limit its use. Recent studies have shown that the vascular density in the DMD patients' muscle is decreased,so muscle are in ischemic and anoxic. Remote ischemic preconditioning(RIPC) can improve the capable of resistanting ischemia and hypoxia and maybe a potential therapy for DMD patients.
Methods: 100 patients (aged 2 to 6 years)will be divided into two groups(treatment and control groups) randomly. Treatment group will receive an RIPC stimulus (inflation of a blood pressure cuff on the bilateral thighs to 150 mm Hg for four 5-minute intervals) while control group will receive a similar stimulus (inflation of a blood pressure cuff on the bilateral thighs to 40 mm Hg for four 5-minute intervals). Serum kinase level ,Blood levels of myoglobin, Evaluation of motor function(Four steps test;6-minute walking test) and MRI of lower limbs）at 0 days, 3 days, 3months ,6months.
Purpose：
548 studies on the registry are indexed under Muscular Dystrophies; 89 are open to participants now.
This study's planned enrollment of 100 is above the median of 24 across 344 interventional studies indexed under Muscular Dystrophies.
Browse Muscular Dystrophies studies →General Hospital of Chinese Armed Police Forces is the lead sponsor of 18 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:Genetic analysis of DMD; from 2 to 6 years old ;without other diseases .
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Exclusion Criteria: other congenital diseases;upper respiratory infection, gastroenteritis, vaccination, trauma.
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inflation of a blood pressure cuff on the bilateral thighs to 150 mm Hg for four 5-minute intervals
Procedure: Remote Ischemic Preconditioning Training Apparatus
inflation of a blood pressure cuff on the bilateral thighs to 40 mm Hg for four 5-minute intervals
Procedure: Remote Ischemic Preconditioning Training Apparatus
Serum CK value
Time frame: 0 day
Serum CK value
Time frame: 3 days
Serum CK value
Time frame: 3 months
Serum CK value
Time frame: 6 months
Serum myoglobin values
Time frame: 0 day
Serum myoglobin values
Time frame: 3 days
Serum myoglobin values
Time frame: 3 months
Serum myoglobin values
Time frame: 6 months
6-minute walking test
Time frame: 0 day
6-minute walking test
Time frame: 3 days
6-minute walking test
Time frame: 3 months
6-minute walking test
Time frame: 6 months
T2 values
Time frame: 0 day
T2 values
Time frame: 3 days
T2 values
Time frame: 3 months
T2 values
Time frame: 6 months
This study is status unknown, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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General Hospital of Chinese Armed Police Forces