An observational study in Aortic Valve Stenosis, Asymptomatic Conditions and Left Ventricular Function, sponsored by European Association of Cardiovascular Imaging. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-02-07.
Sponsored by European Association of Cardiovascular Imaging · Observational
In patients with asymptomatic aortic stenosis (AS), the prognostic value of reduced left ventricular (LV) ejection fraction is well known. Consequently, there is class I indication for surgery in these patients when LV ejection fraction \<50%. However, there is growing evidences suggesting that subclinical LV dysfunction, and more particularly longitudinal myocardial dysfunction, may be a powerful early predictor of outcome, even when LV ejection is still preserved. In asymptomatic AS patients with LV ejection fraction >50%, a reduced LV global longitudinal strain, as assessed using speckle tracking imaging with transthoracic echocardiography, may be an accurate marker to identify early subclinical LV dysfunction and thus, to improve the risk stratification, the management and the timing of surgery. Several mono-centric observational small studies recently reported results emphasizing the role of LV global longitudinal strain in AS patients. Therefore, a meta-analysis may be conducted and may provide meaningful data. The investigators hypothesized that LV global longitudinal strain is a determinant of outcome in asymptomatic patients with AS and preserved LV ejection fraction.
985 studies on the registry are indexed under Aortic Valve Stenosis; 283 are open to participants now.
This study's enrollment of 1,000 is above the median of 200 across 424 observational studies indexed under Aortic Valve Stenosis.
Browse Aortic Valve Stenosis studies →This is the only study on the registry with European Association of Cardiovascular Imaging as lead sponsor.
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Asymptomatic patients with at least moderate aortic stenosis (mean pressure gradient >25mmHg or aortic valve area \<1.5cm²) and left ventricular ejection fraction >50%.
Exclusion Criteria:
Patients will be compared according to the level of LV global longitudinal strain (GLS) as derived from transthoracic echocardiography and speckle tracking analysis. Two groups will be compared regarding outcome: preserved LV GLS vs. reduced LV GLS. The definition use for reduced LV GLS will be \>-16%. An optimal threshold would also be calculated and derived from the pooled data.
The definition use for reduced LV GLS will be \>-16%. An optimal threshold would also be calculated and derived from the pooled data.
Combined outcome of death and cardiovascular-related hospitalization (including aortic valve replacement)
Time frame: up to 10 years
Combined outcome of death and cardiovascular-related hospitalization (without aortic valve replacement)
Time frame: up to 10 years
This study is status unknown, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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