An interventional study of kidney treatment bundle (KDIGO) in Acute Kidney Injury, sponsored by Wuerzburg University Hospital. Withdrawn at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-06-01.
Sponsored by Wuerzburg University Hospital · Not applicable, Interventional, and Prevention
Postoperative acute kidney injury (AKI) refers to increased mortality and morbidity in patients after non-cardiac surgery. The Kidney Disease Improving Global Outcomes (KDIGO)-guidelines recommend a bundle of procedures to prevent the occurrence of AKI: A protocol for the improvement of the hemodynamic situation and a standardized proceeding in hemodynamic monitoring, consequent avoidance of nephrotoxic substances, regular measurement of creatinine and urine output, as well as normoglycemia. The primary goal is to determine if the consequent application of the KDIGO-bundle leads to a prevention of the occurrence of AKI in patients at risk after non-cardiac surgery.
All patients included in the study will be treated with the KDIGO-bundle (hemodynamic stabilization, avoidance of nephrotoxic substances, normoglycemia and measurement of creatinine in serum and urine output). 12 h, 24h as well as on day 2, 3, 5 and 10 after admission on ICU the occurence of AKI (according to KDIGO) will be assessed.
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
Browse Acute Kidney Injury studies →Wuerzburg University Hospital is the lead sponsor of 96 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria:
Consequent postoperative application of a kidney treatment bundle: Protocol based hemodynamic optimization and monitoring, regular screening of creatinine in serum and of urine output, no use of potential nephrotoxic medication and normoglycemia.
Procedure: kidney treatment bundle (KDIGO)
Application of the measures of the kidney treatment bundle.
Incidence of postoperative AKI
AKI according to KDIGO definition
Time frame: until day 5 after surgery
Intensive care unit mortality
Time frame: 28 days and 90 days after surgery
hospital mortality
Time frame: up to 100 days after surgery
usage of renal replacement therapy (hours)
Time frame: up to 30 days after surgery
length of invasive respirator therapy (hours)
Time frame: up to 30 days after surgery
creatinine in serum
Time frame: 12 hours, day 2, 3, 5 and 10 after surgery
urine output (total ml)
Time frame: after 12 hours, on day 2 (in 24hour), 3 (in 24hour), 5 (in 24hour) and 10 (in 24hour) after surgery
length of hospital stay
Time frame: up to 100 days after surgery
length of ICU stay
Time frame: up to 100 days after surgery
This study is withdrawn, as verified in May 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Wuerzburg University Hospital